Deciphering metabolic networks

Oliver Fiehn, Wolfram Weckwerth

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

All higher organisms divide major biochemical steps into different cellular compartments and often use tissue-specific division of metabolism for the same purpose. Such spatial resolution is accompanied with temporal changes of metabolite synthesis in response to environmental stimuli or developmental needs. Although analyses of primary and secondary gene products, i.e. transcripts, proteins, and metabolites, regularly do not cope with this spatial and temporal resolution, these gene products are often observed to be highly coregulated forming complex networks. Methods to study such networks are reviewed with respect to data acquisition, network statistics, and biochemical interpretation.

Original languageEnglish (US)
Pages (from-to)579-588
Number of pages10
JournalEuropean Journal of Biochemistry
Volume270
Issue number4
DOIs
StatePublished - Feb 2003
Externally publishedYes

    Fingerprint

Keywords

  • Metabolite networks
  • Metabolite profiling
  • Metabolomics
  • Protein networks
  • Proteomics

ASJC Scopus subject areas

  • Biochemistry

Cite this