Decalcified tooth matrix powder induces new bone formation and hematopoietic microenvironment in the mouse

W. H. Knospe, S. G. Husseini, S. S. Adler, A Hari Reddi

Research output: Contribution to journalArticle

7 Scopus citations


Implants of bone and tooth matrix powder were placed subcutaneously (s.c.) on intraperitoneal (i.p.) Mitex or Polyvic membranes. Implants were removed for histology after 1-24 weeks. Macrophages, fibroblasts, and vascular sinusoids infiltrated around bone and tooth matrix particles after one week. In the s.c. tooth matrix implants, a few sites of cartilage formation and ossification developed at two weeks, and by three weeks granulocytopoiesis and megakaryocytopoiesis developed adjacent to new bone; erythropoiesis was not observed. In s.c. bone matrix implants and in the i.p. artificial membranes coasted with bone or tooth matrix powder, ossification or hematopoiesis was not observed. Small numbers of CFU-s, CFU-nm, BFU-e, and CFU-e appeared 10-20 days after s.c. implantation of tooth matrix; none were detected in s.c. bone matrix implants.

Original languageEnglish (US)
Pages (from-to)320-329
Number of pages10
JournalInternational Journal of Cell Cloning
Issue number5
StatePublished - 1985
Externally publishedYes


ASJC Scopus subject areas

  • Cell Biology

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