Deaths among tuberculosis cases in Shanghai, China: Who is at risk?

Xin Shen, Kathryn DeRiemer, Zheng'an Yuan, Mei Shen, Zhen Xia, Xiaohong Gui, Lili Wang, Jian Mei

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Information about the risk factors associated with death caused by tuberculosis (TB) or death with TB would allow improvements in the clinical care of TB patients and save lives. The present study sought to identify characteristics associated with increased risk of death during anti-TB treatment in Shanghai, a city in China with one of the country's highest TB mortality rates. Methods: We evaluated deaths among culture positive pulmonary TB cases that were diagnosed in Shanghai during 2000-2004 and initiated anti-TB therapy. Demographic, clinical, mycobacteriological information and treatment outcomes were routinely collected through a mandatory reporting system. Results: There were 7,999 culture positive pulmonary cases reported during the study period. The overall case fatality rate was 5.5% (440 cases), and approximately half (50.5%) of the deaths were attributed to causes other than TB. Eighty-six percent of the deaths were among TB cases age ≥ 60 years. The significant independent risk factors for mortality during anti-TB treatment were advancing age, male sex, sputum smear positivity, and the presence of a comorbidity. Conclusion: More vigorous clinical management and prevention strategies by both the TB control program and other public health programs are essential to improve TB treatment outcomes. Earlier suspicion, diagnosis and treatment of TB, especially among persons older than 60 years of age and those with a comorbid condition, could reduce deaths among TB patients.

Original languageEnglish (US)
Article number95
JournalBMC Infectious Diseases
Volume9
DOIs
StatePublished - Jun 17 2009

Fingerprint

China
Tuberculosis
Mortality
Mandatory Reporting
Therapeutics
Sputum
Pulmonary Tuberculosis
Comorbidity
Early Diagnosis
Patient Care
Public Health
Demography
Lung

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Shen, X., DeRiemer, K., Yuan, Z., Shen, M., Xia, Z., Gui, X., ... Mei, J. (2009). Deaths among tuberculosis cases in Shanghai, China: Who is at risk? BMC Infectious Diseases, 9, [95]. https://doi.org/10.1186/1471-2334-9-95

Deaths among tuberculosis cases in Shanghai, China : Who is at risk? / Shen, Xin; DeRiemer, Kathryn; Yuan, Zheng'an; Shen, Mei; Xia, Zhen; Gui, Xiaohong; Wang, Lili; Mei, Jian.

In: BMC Infectious Diseases, Vol. 9, 95, 17.06.2009.

Research output: Contribution to journalArticle

Shen, X, DeRiemer, K, Yuan, Z, Shen, M, Xia, Z, Gui, X, Wang, L & Mei, J 2009, 'Deaths among tuberculosis cases in Shanghai, China: Who is at risk?', BMC Infectious Diseases, vol. 9, 95. https://doi.org/10.1186/1471-2334-9-95
Shen, Xin ; DeRiemer, Kathryn ; Yuan, Zheng'an ; Shen, Mei ; Xia, Zhen ; Gui, Xiaohong ; Wang, Lili ; Mei, Jian. / Deaths among tuberculosis cases in Shanghai, China : Who is at risk?. In: BMC Infectious Diseases. 2009 ; Vol. 9.
@article{2e308a8c9fb84d98af39d9b2b4616f5e,
title = "Deaths among tuberculosis cases in Shanghai, China: Who is at risk?",
abstract = "Background: Information about the risk factors associated with death caused by tuberculosis (TB) or death with TB would allow improvements in the clinical care of TB patients and save lives. The present study sought to identify characteristics associated with increased risk of death during anti-TB treatment in Shanghai, a city in China with one of the country's highest TB mortality rates. Methods: We evaluated deaths among culture positive pulmonary TB cases that were diagnosed in Shanghai during 2000-2004 and initiated anti-TB therapy. Demographic, clinical, mycobacteriological information and treatment outcomes were routinely collected through a mandatory reporting system. Results: There were 7,999 culture positive pulmonary cases reported during the study period. The overall case fatality rate was 5.5{\%} (440 cases), and approximately half (50.5{\%}) of the deaths were attributed to causes other than TB. Eighty-six percent of the deaths were among TB cases age ≥ 60 years. The significant independent risk factors for mortality during anti-TB treatment were advancing age, male sex, sputum smear positivity, and the presence of a comorbidity. Conclusion: More vigorous clinical management and prevention strategies by both the TB control program and other public health programs are essential to improve TB treatment outcomes. Earlier suspicion, diagnosis and treatment of TB, especially among persons older than 60 years of age and those with a comorbid condition, could reduce deaths among TB patients.",
author = "Xin Shen and Kathryn DeRiemer and Zheng'an Yuan and Mei Shen and Zhen Xia and Xiaohong Gui and Lili Wang and Jian Mei",
year = "2009",
month = "6",
day = "17",
doi = "10.1186/1471-2334-9-95",
language = "English (US)",
volume = "9",
journal = "BMC Infectious Diseases",
issn = "1471-2334",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Deaths among tuberculosis cases in Shanghai, China

T2 - Who is at risk?

AU - Shen, Xin

AU - DeRiemer, Kathryn

AU - Yuan, Zheng'an

AU - Shen, Mei

AU - Xia, Zhen

AU - Gui, Xiaohong

AU - Wang, Lili

AU - Mei, Jian

PY - 2009/6/17

Y1 - 2009/6/17

N2 - Background: Information about the risk factors associated with death caused by tuberculosis (TB) or death with TB would allow improvements in the clinical care of TB patients and save lives. The present study sought to identify characteristics associated with increased risk of death during anti-TB treatment in Shanghai, a city in China with one of the country's highest TB mortality rates. Methods: We evaluated deaths among culture positive pulmonary TB cases that were diagnosed in Shanghai during 2000-2004 and initiated anti-TB therapy. Demographic, clinical, mycobacteriological information and treatment outcomes were routinely collected through a mandatory reporting system. Results: There were 7,999 culture positive pulmonary cases reported during the study period. The overall case fatality rate was 5.5% (440 cases), and approximately half (50.5%) of the deaths were attributed to causes other than TB. Eighty-six percent of the deaths were among TB cases age ≥ 60 years. The significant independent risk factors for mortality during anti-TB treatment were advancing age, male sex, sputum smear positivity, and the presence of a comorbidity. Conclusion: More vigorous clinical management and prevention strategies by both the TB control program and other public health programs are essential to improve TB treatment outcomes. Earlier suspicion, diagnosis and treatment of TB, especially among persons older than 60 years of age and those with a comorbid condition, could reduce deaths among TB patients.

AB - Background: Information about the risk factors associated with death caused by tuberculosis (TB) or death with TB would allow improvements in the clinical care of TB patients and save lives. The present study sought to identify characteristics associated with increased risk of death during anti-TB treatment in Shanghai, a city in China with one of the country's highest TB mortality rates. Methods: We evaluated deaths among culture positive pulmonary TB cases that were diagnosed in Shanghai during 2000-2004 and initiated anti-TB therapy. Demographic, clinical, mycobacteriological information and treatment outcomes were routinely collected through a mandatory reporting system. Results: There were 7,999 culture positive pulmonary cases reported during the study period. The overall case fatality rate was 5.5% (440 cases), and approximately half (50.5%) of the deaths were attributed to causes other than TB. Eighty-six percent of the deaths were among TB cases age ≥ 60 years. The significant independent risk factors for mortality during anti-TB treatment were advancing age, male sex, sputum smear positivity, and the presence of a comorbidity. Conclusion: More vigorous clinical management and prevention strategies by both the TB control program and other public health programs are essential to improve TB treatment outcomes. Earlier suspicion, diagnosis and treatment of TB, especially among persons older than 60 years of age and those with a comorbid condition, could reduce deaths among TB patients.

UR - http://www.scopus.com/inward/record.url?scp=67649951544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649951544&partnerID=8YFLogxK

U2 - 10.1186/1471-2334-9-95

DO - 10.1186/1471-2334-9-95

M3 - Article

C2 - 19531267

AN - SCOPUS:67649951544

VL - 9

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

SN - 1471-2334

M1 - 95

ER -