Death-associated protein kinase-mediated cell death modulated by interaction with DANGER

Bingnan N. Kang, Abdullah S. Ahmad, Sofiyan Saleem, Randen L. Patterson, Lynda Hester, Sylvain Doré, Solomon H. Snyder

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Death-associated protein kinase (DAPK) is a key player in multiple cell death signaling pathways. We report that DAPK is regulated by DANGER, a partial MAB-21 domain-containing protein. DANGER binds directly to DAPK and inhibits DAPK catalytic activity. DANGER-deficient mouse embryonic fibroblasts and neurons exhibit greater DAPK activity and increased sensitivity to cell death stimuli than do wild-type control cells. In addition, DANGER-deficient mice manifest more severe brain damage after acute excitotoxicity and transient cerebral ischemia than do control mice. Accordingly, DANGER may physiologically regulate the viability of neurons and represent a potential therapeutic target for stroke and neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)93-98
Number of pages6
JournalJournal of Neuroscience
Volume30
Issue number1
DOIs
StatePublished - Jan 6 2010
Externally publishedYes

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Death-Associated Protein Kinases
Cell Death
Neurons
Transient Ischemic Attack
Neurodegenerative Diseases
Fibroblasts
Stroke
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kang, B. N., Ahmad, A. S., Saleem, S., Patterson, R. L., Hester, L., Doré, S., & Snyder, S. H. (2010). Death-associated protein kinase-mediated cell death modulated by interaction with DANGER. Journal of Neuroscience, 30(1), 93-98. https://doi.org/10.1523/JNEUROSCI.3974-09.2010

Death-associated protein kinase-mediated cell death modulated by interaction with DANGER. / Kang, Bingnan N.; Ahmad, Abdullah S.; Saleem, Sofiyan; Patterson, Randen L.; Hester, Lynda; Doré, Sylvain; Snyder, Solomon H.

In: Journal of Neuroscience, Vol. 30, No. 1, 06.01.2010, p. 93-98.

Research output: Contribution to journalArticle

Kang, BN, Ahmad, AS, Saleem, S, Patterson, RL, Hester, L, Doré, S & Snyder, SH 2010, 'Death-associated protein kinase-mediated cell death modulated by interaction with DANGER', Journal of Neuroscience, vol. 30, no. 1, pp. 93-98. https://doi.org/10.1523/JNEUROSCI.3974-09.2010
Kang, Bingnan N. ; Ahmad, Abdullah S. ; Saleem, Sofiyan ; Patterson, Randen L. ; Hester, Lynda ; Doré, Sylvain ; Snyder, Solomon H. / Death-associated protein kinase-mediated cell death modulated by interaction with DANGER. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 1. pp. 93-98.
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