Deactivation mechanisms of rod phototransduction

The cogan lecture

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The absorption of photons in rods and cones of the retina activate homologous biochemical signaling cascades that lead to the electrical changes that subserve the first steps in vision. Persistent activity of the cascade interferes with the ability of the photoreceptor to signal the absorption of subsequent photons, ultimately limiting the photoreceptor's sensitivity and temporal resolution. This article summarizes recent work on transgenic and knockout mouse rods that has revealed the deactivation mechanisms essential for normal response recovery and how each of these processes contributes to the overall time course of the flash response of rods.

Original languageEnglish (US)
Pages (from-to)1283-1288
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume51
Issue number3
DOIs
StatePublished - Mar 2010

Fingerprint

Light Signal Transduction
Photons
Retinal Cone Photoreceptor Cells
Retinal Rod Photoreceptor Cells
Vertebrate Photoreceptor Cells
Aptitude
Knockout Mice
Transgenic Mice

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Deactivation mechanisms of rod phototransduction : The cogan lecture. / Burns, Marie E.

In: Investigative Ophthalmology and Visual Science, Vol. 51, No. 3, 03.2010, p. 1283-1288.

Research output: Contribution to journalArticle

@article{f13aebe8befe4db1a4220fab166d87dc,
title = "Deactivation mechanisms of rod phototransduction: The cogan lecture",
abstract = "The absorption of photons in rods and cones of the retina activate homologous biochemical signaling cascades that lead to the electrical changes that subserve the first steps in vision. Persistent activity of the cascade interferes with the ability of the photoreceptor to signal the absorption of subsequent photons, ultimately limiting the photoreceptor's sensitivity and temporal resolution. This article summarizes recent work on transgenic and knockout mouse rods that has revealed the deactivation mechanisms essential for normal response recovery and how each of these processes contributes to the overall time course of the flash response of rods.",
author = "Burns, {Marie E}",
year = "2010",
month = "3",
doi = "10.1167/iovs.09-4366",
language = "English (US)",
volume = "51",
pages = "1283--1288",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "3",

}

TY - JOUR

T1 - Deactivation mechanisms of rod phototransduction

T2 - The cogan lecture

AU - Burns, Marie E

PY - 2010/3

Y1 - 2010/3

N2 - The absorption of photons in rods and cones of the retina activate homologous biochemical signaling cascades that lead to the electrical changes that subserve the first steps in vision. Persistent activity of the cascade interferes with the ability of the photoreceptor to signal the absorption of subsequent photons, ultimately limiting the photoreceptor's sensitivity and temporal resolution. This article summarizes recent work on transgenic and knockout mouse rods that has revealed the deactivation mechanisms essential for normal response recovery and how each of these processes contributes to the overall time course of the flash response of rods.

AB - The absorption of photons in rods and cones of the retina activate homologous biochemical signaling cascades that lead to the electrical changes that subserve the first steps in vision. Persistent activity of the cascade interferes with the ability of the photoreceptor to signal the absorption of subsequent photons, ultimately limiting the photoreceptor's sensitivity and temporal resolution. This article summarizes recent work on transgenic and knockout mouse rods that has revealed the deactivation mechanisms essential for normal response recovery and how each of these processes contributes to the overall time course of the flash response of rods.

UR - http://www.scopus.com/inward/record.url?scp=77949892579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949892579&partnerID=8YFLogxK

U2 - 10.1167/iovs.09-4366

DO - 10.1167/iovs.09-4366

M3 - Article

VL - 51

SP - 1283

EP - 1288

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 3

ER -