Deactivation mechanisms of rod phototransduction: The cogan lecture

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The absorption of photons in rods and cones of the retina activate homologous biochemical signaling cascades that lead to the electrical changes that subserve the first steps in vision. Persistent activity of the cascade interferes with the ability of the photoreceptor to signal the absorption of subsequent photons, ultimately limiting the photoreceptor's sensitivity and temporal resolution. This article summarizes recent work on transgenic and knockout mouse rods that has revealed the deactivation mechanisms essential for normal response recovery and how each of these processes contributes to the overall time course of the flash response of rods.

Original languageEnglish (US)
Pages (from-to)1283-1288
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - Mar 2010

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)


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