DDT exposure in utero and breast cancer

Barbara A. Cohn, Michele La Merrill, Nickilou Y. Krigbaum, Gregory Yeh, June Soo Park, Lauren Zimmermann, Piera M. Cirillo

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Context: Currently no direct evidence links in utero dichlorodiphenyltrichloroethane (DDT) exposure to human breast cancer. However, in utero exposure to another xenoestrogen, diethylstilbestrol, predicts an increased breast cancer risk. If this finding extends to DDT, it could have far-reaching consequences. Many women were heavily exposed in utero during widespread DDT use in the 1960s. They are now reaching the age of heightened breast cancer risk. DDT exposure persists and use continues in Africa and Asia without clear knowledge of the consequences for the next generation. Hypothesis: In utero exposure to DDT is associated with an increased risk of breast cancer. Design: This was a case-control study nested in a prospective 54-year follow-up of 9300 daughters in the Child Health and Development Studies pregnancy cohort (n = 118 breast cancer cases, diagnosed by age 52 y and 354 controls matched on birth year). Setting and Participants: Kaiser Foundation Health Plan members who received obstetric care in Alameda County, California, from 1959 to 1967, and their adult daughters participated in the study. Main Outcome Measure: Daughters' breast cancer diagnosed by age 52 years as of 2012 was measured. Results: Maternal o,p'-DDT predicted daughters' breast cancer (odds ratio fourth quartile vs first = 3.7, 95% confidence interval 1.5-9.0). Mothers' lipids, weight, race, age, and breast cancer history did not explain the findings. Conclusions: This prospective human study links measured DDT exposure in utero to risk of breast cancer. Experimental studies are essential to confirm results and discover causal mechanisms. Findings support classification of DDT as an endocrine disruptor, a predictor of breast cancer, and a marker of high risk.

Original languageEnglish (US)
Pages (from-to)2865-2872
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number8
DOIs
StatePublished - Jan 1 2015

Fingerprint

Breast Neoplasms
Nuclear Family
Health
Obstetrics
Endocrine Disruptors
Diethylstilbestrol
Mothers
Lipids
Adult Children
Child Development
Case-Control Studies
Cohort Studies
Odds Ratio
Outcome Assessment (Health Care)
Parturition
Prospective Studies
Confidence Intervals
Weights and Measures
Pregnancy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Cohn, B. A., La Merrill, M., Krigbaum, N. Y., Yeh, G., Park, J. S., Zimmermann, L., & Cirillo, P. M. (2015). DDT exposure in utero and breast cancer. Journal of Clinical Endocrinology and Metabolism, 100(8), 2865-2872. https://doi.org/10.1210/jc.2015-1841

DDT exposure in utero and breast cancer. / Cohn, Barbara A.; La Merrill, Michele; Krigbaum, Nickilou Y.; Yeh, Gregory; Park, June Soo; Zimmermann, Lauren; Cirillo, Piera M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 8, 01.01.2015, p. 2865-2872.

Research output: Contribution to journalArticle

Cohn, BA, La Merrill, M, Krigbaum, NY, Yeh, G, Park, JS, Zimmermann, L & Cirillo, PM 2015, 'DDT exposure in utero and breast cancer', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 8, pp. 2865-2872. https://doi.org/10.1210/jc.2015-1841
Cohn, Barbara A. ; La Merrill, Michele ; Krigbaum, Nickilou Y. ; Yeh, Gregory ; Park, June Soo ; Zimmermann, Lauren ; Cirillo, Piera M. / DDT exposure in utero and breast cancer. In: Journal of Clinical Endocrinology and Metabolism. 2015 ; Vol. 100, No. 8. pp. 2865-2872.
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