TY - JOUR
T1 - Daylight-induced antibacterial and antiviral nanofibrous membranes containing Vitamin K derivatives for personal protective equipment
AU - Sun, Gang
AU - Zhang, Zheng
AU - El-Moghazy, Ahmed Y.
AU - Wisuthiphaet, Nicharee
AU - Nitin, Nitin
AU - Castillo, Diego
AU - Murphy, Brian G.
N1 - Funding Information:
This work was partially supported by the COVID-19 Research Accelerator Funding Track Program (# 19933) at the University of California, Davis and a USDA-NIFA grant (2015-68003-23411).
PY - 2020
Y1 - 2020
N2 - During the development of antibacterial and antiviral materials for personal protective equipment (PPE), daylight active functional polymeric materials containing vitamin K compounds (VKs) and impacts of polymer structures to the functions were investigated. As examples, hydrophobic polyacrylonitrile (PAN) and hydrophilic poly(vinyl alcohol-co-ethylene) (PVA-co-PE) polymers were directly blended with three VK compounds and electrospun into VK-containing nanofibrous membranes (VNFMs). The prepared VNFMs exhibited robust photoactivity in generating reactive oxygen species (ROS) under both daylight (D65, 300−800 nm) and ultraviolet A (UVA, 365 nm) irradiation, resulting in high antimicrobial and antiviral efficiency (>99.9%) within a short exposure time (<90 min). Interestingly, the PVA-co-PE/VK3 VNFM showed higher ROS production rates and better biocidal functions than those of the PAN/VK3 VNFM under the same photoirradiation conditions, indicating that PVA-coPE is a better matrix polymer material for these functions. Moreover, the prepared PVA-co-PE/VK3 VNFM maintains its powerful microbicidal function even after five times of repeated exposures to bacteria and viruses, showing the stability and reusability of the antimicrobial materials. The fabrication of photoinduced antimicrobial VNFMs may provide new insights into the development of non-toxic and reusable photoinduced antimicrobial materials that could be applied in personal protective equipment with improved biological protections.
AB - During the development of antibacterial and antiviral materials for personal protective equipment (PPE), daylight active functional polymeric materials containing vitamin K compounds (VKs) and impacts of polymer structures to the functions were investigated. As examples, hydrophobic polyacrylonitrile (PAN) and hydrophilic poly(vinyl alcohol-co-ethylene) (PVA-co-PE) polymers were directly blended with three VK compounds and electrospun into VK-containing nanofibrous membranes (VNFMs). The prepared VNFMs exhibited robust photoactivity in generating reactive oxygen species (ROS) under both daylight (D65, 300−800 nm) and ultraviolet A (UVA, 365 nm) irradiation, resulting in high antimicrobial and antiviral efficiency (>99.9%) within a short exposure time (<90 min). Interestingly, the PVA-co-PE/VK3 VNFM showed higher ROS production rates and better biocidal functions than those of the PAN/VK3 VNFM under the same photoirradiation conditions, indicating that PVA-coPE is a better matrix polymer material for these functions. Moreover, the prepared PVA-co-PE/VK3 VNFM maintains its powerful microbicidal function even after five times of repeated exposures to bacteria and viruses, showing the stability and reusability of the antimicrobial materials. The fabrication of photoinduced antimicrobial VNFMs may provide new insights into the development of non-toxic and reusable photoinduced antimicrobial materials that could be applied in personal protective equipment with improved biological protections.
KW - Biocidal PPE
KW - Nanofibrous membranes
KW - Photoinduced antimicrobial and antiviral
KW - Photoinduced generation of reactive oxygen species
KW - Vitamin K derivatives
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U2 - 10.1021/acsami.0c14883
DO - 10.1021/acsami.0c14883
M3 - Article
C2 - 33089989
AN - SCOPUS:85095668484
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
ER -