Day care, childhood infections, and risk of neuroblastoma

Florence Menegaux, Andrew F. Olshan, Joseph P. Neglia, Bradley H Pollock, Melissa L. Bondy

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Neuroblastoma is the most common cancer in infants worldwide, but little is known about its etiology. Infectious etiologies involving the immune system have been hypothesized for some childhood cancers, especially leukemia, but the role of infectious agents in neuroblastoma has not been fully investigated. The authors used data from a large case-control study conducted by the Children's Oncology Group in the United States and Canada in 1992-1994 to investigate whether there was any relation among day-care attendance, childhood infections, allergies, and neuroblastoma. They interviewed mothers of 538 case children and 504 age-matched control children by telephone about several factors, including pregnancy, medical history, lifestyle, and childhood medical conditions and exposures. The results suggested decreased risks associated with day-care attendance (odds ratio (OR) = 0.81, 95% confidence interval (CI): 0.56, 1.17), childhood infectious diseases (chickenpox, mumps, red measles, and German measles) (OR = 0.60, 95% CI: 0.39, 0.93), and allergies (OR = 0.68, 95% CI: 0.44, 1.07). The authors found reduced neuroblastoma risk associated with markers of potential childhood infections. This suggests a possible role of infectious agents in neuroblastoma etiology. Future epidemiologic studies should incorporate more direct data on infection.

Original languageEnglish (US)
Pages (from-to)843-851
Number of pages9
JournalAmerican Journal of Epidemiology
Volume159
Issue number9
DOIs
StatePublished - May 1 2004
Externally publishedYes

Fingerprint

Neuroblastoma
Infection
Odds Ratio
Confidence Intervals
Hypersensitivity
Reproductive History
Mumps
Chickenpox
Rubella
Measles
Telephone
Canada
Communicable Diseases
Case-Control Studies
Life Style
Epidemiologic Studies
Immune System
Neoplasms
Leukemia
Mothers

Keywords

  • Child
  • Day care
  • Hypersensitivity
  • Infection
  • Neuroblastoma

ASJC Scopus subject areas

  • Epidemiology

Cite this

Day care, childhood infections, and risk of neuroblastoma. / Menegaux, Florence; Olshan, Andrew F.; Neglia, Joseph P.; Pollock, Bradley H; Bondy, Melissa L.

In: American Journal of Epidemiology, Vol. 159, No. 9, 01.05.2004, p. 843-851.

Research output: Contribution to journalArticle

Menegaux, Florence ; Olshan, Andrew F. ; Neglia, Joseph P. ; Pollock, Bradley H ; Bondy, Melissa L. / Day care, childhood infections, and risk of neuroblastoma. In: American Journal of Epidemiology. 2004 ; Vol. 159, No. 9. pp. 843-851.
@article{f3ec05e06edc426c8dfb6b392191db2d,
title = "Day care, childhood infections, and risk of neuroblastoma",
abstract = "Neuroblastoma is the most common cancer in infants worldwide, but little is known about its etiology. Infectious etiologies involving the immune system have been hypothesized for some childhood cancers, especially leukemia, but the role of infectious agents in neuroblastoma has not been fully investigated. The authors used data from a large case-control study conducted by the Children's Oncology Group in the United States and Canada in 1992-1994 to investigate whether there was any relation among day-care attendance, childhood infections, allergies, and neuroblastoma. They interviewed mothers of 538 case children and 504 age-matched control children by telephone about several factors, including pregnancy, medical history, lifestyle, and childhood medical conditions and exposures. The results suggested decreased risks associated with day-care attendance (odds ratio (OR) = 0.81, 95{\%} confidence interval (CI): 0.56, 1.17), childhood infectious diseases (chickenpox, mumps, red measles, and German measles) (OR = 0.60, 95{\%} CI: 0.39, 0.93), and allergies (OR = 0.68, 95{\%} CI: 0.44, 1.07). The authors found reduced neuroblastoma risk associated with markers of potential childhood infections. This suggests a possible role of infectious agents in neuroblastoma etiology. Future epidemiologic studies should incorporate more direct data on infection.",
keywords = "Child, Day care, Hypersensitivity, Infection, Neuroblastoma",
author = "Florence Menegaux and Olshan, {Andrew F.} and Neglia, {Joseph P.} and Pollock, {Bradley H} and Bondy, {Melissa L.}",
year = "2004",
month = "5",
day = "1",
doi = "10.1093/aje/kwh111",
language = "English (US)",
volume = "159",
pages = "843--851",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Day care, childhood infections, and risk of neuroblastoma

AU - Menegaux, Florence

AU - Olshan, Andrew F.

AU - Neglia, Joseph P.

AU - Pollock, Bradley H

AU - Bondy, Melissa L.

PY - 2004/5/1

Y1 - 2004/5/1

N2 - Neuroblastoma is the most common cancer in infants worldwide, but little is known about its etiology. Infectious etiologies involving the immune system have been hypothesized for some childhood cancers, especially leukemia, but the role of infectious agents in neuroblastoma has not been fully investigated. The authors used data from a large case-control study conducted by the Children's Oncology Group in the United States and Canada in 1992-1994 to investigate whether there was any relation among day-care attendance, childhood infections, allergies, and neuroblastoma. They interviewed mothers of 538 case children and 504 age-matched control children by telephone about several factors, including pregnancy, medical history, lifestyle, and childhood medical conditions and exposures. The results suggested decreased risks associated with day-care attendance (odds ratio (OR) = 0.81, 95% confidence interval (CI): 0.56, 1.17), childhood infectious diseases (chickenpox, mumps, red measles, and German measles) (OR = 0.60, 95% CI: 0.39, 0.93), and allergies (OR = 0.68, 95% CI: 0.44, 1.07). The authors found reduced neuroblastoma risk associated with markers of potential childhood infections. This suggests a possible role of infectious agents in neuroblastoma etiology. Future epidemiologic studies should incorporate more direct data on infection.

AB - Neuroblastoma is the most common cancer in infants worldwide, but little is known about its etiology. Infectious etiologies involving the immune system have been hypothesized for some childhood cancers, especially leukemia, but the role of infectious agents in neuroblastoma has not been fully investigated. The authors used data from a large case-control study conducted by the Children's Oncology Group in the United States and Canada in 1992-1994 to investigate whether there was any relation among day-care attendance, childhood infections, allergies, and neuroblastoma. They interviewed mothers of 538 case children and 504 age-matched control children by telephone about several factors, including pregnancy, medical history, lifestyle, and childhood medical conditions and exposures. The results suggested decreased risks associated with day-care attendance (odds ratio (OR) = 0.81, 95% confidence interval (CI): 0.56, 1.17), childhood infectious diseases (chickenpox, mumps, red measles, and German measles) (OR = 0.60, 95% CI: 0.39, 0.93), and allergies (OR = 0.68, 95% CI: 0.44, 1.07). The authors found reduced neuroblastoma risk associated with markers of potential childhood infections. This suggests a possible role of infectious agents in neuroblastoma etiology. Future epidemiologic studies should incorporate more direct data on infection.

KW - Child

KW - Day care

KW - Hypersensitivity

KW - Infection

KW - Neuroblastoma

UR - http://www.scopus.com/inward/record.url?scp=2342587510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342587510&partnerID=8YFLogxK

U2 - 10.1093/aje/kwh111

DO - 10.1093/aje/kwh111

M3 - Article

VL - 159

SP - 843

EP - 851

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 9

ER -