Daunomycin administered by continuous intravenous infusion is effective in the treatment of acute nonlymphocytic leukaemia

J. P. Lewis, Frederick J Meyers, L. Tanaka

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Anthracyclines given by continuous infusion, as opposed to bolus administration, are associated with a reduced incidence of cardiac and gastrointestinal toxicity. Our study was developed to test the antileukaemic effect of anthracyclines given as a continuous infusion. Nineteen sequential patients admitted for treatment of acute nonlymphocytic leukaemia (ANLL) were managed with a regimen utilizing a 3 d continuous intravenous infusion of daunomycin (DNM), and the complete response rate was similar to this institution's past experience with antileukaemic regimens employing 3 d bolus DNM. In our studies, infusion DNM was at least as myelotoxic and antileukaemic as bolus DNM; thus this method of administration should be explored further in remission-induction regimens for ANLL.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalBritish Journal of Haematology
Volume61
Issue number2
StatePublished - 1985

ASJC Scopus subject areas

  • Hematology

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