Darier-white disease

Mitalee P. Christman, Evan Rieder, Randie H. Kim, Nooshin Brinster, Alisa Femia, Miriam Keltz Pomeranz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We present a 58-year-old woman with bipolar disorder and with a longstanding history of yellowbrown, hyperkeratotic papules in a seborrheic distribution and nail changes. Her father and paternal grandmother had similar eruptions and also had psychiatric disease. Histopathologic examination showed acantholysis and dyskeratosis, which was consistent with Darier-White disease. Darier-White disease is a rare, hereditary disorder that is inherited in an autosomal dominant manner and that usually presents in adolescence or early adulthood due to mutations in the SERCA2 calcium pump. The resultant alterations in calcium homeostasis affect desmosome assembly and lead to acantholysis and apoptosis, which creates the characteristic eruption. Genetic linkage analysis of affected families shows that a susceptibility locus for bipolar disorder cosegregates with genetic markers that are found in the Darier-White disease region. Treatments, which include topical emollients, mild keratolytics, and topical or oral retinoids, are aimed at improving the appearance of skin, relieving symptoms, and preventing or treating infectious complications.

Original languageEnglish (US)
Pages (from-to)45-47
Number of pages3
JournalDermatology Online Journal
Volume22
Issue number12
StatePublished - 2016

Fingerprint

Darier Disease
Acantholysis
Bipolar Disorder
Emollients
Calcium
Desmosomes
Genetic Linkage
Retinoids
Nails
Genetic Markers
Fathers
Psychiatry
Homeostasis
Apoptosis
Skin
Mutation
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Christman, M. P., Rieder, E., Kim, R. H., Brinster, N., Femia, A., & Pomeranz, M. K. (2016). Darier-white disease. Dermatology Online Journal, 22(12), 45-47.

Darier-white disease. / Christman, Mitalee P.; Rieder, Evan; Kim, Randie H.; Brinster, Nooshin; Femia, Alisa; Pomeranz, Miriam Keltz.

In: Dermatology Online Journal, Vol. 22, No. 12, 2016, p. 45-47.

Research output: Contribution to journalArticle

Christman, MP, Rieder, E, Kim, RH, Brinster, N, Femia, A & Pomeranz, MK 2016, 'Darier-white disease', Dermatology Online Journal, vol. 22, no. 12, pp. 45-47.
Christman MP, Rieder E, Kim RH, Brinster N, Femia A, Pomeranz MK. Darier-white disease. Dermatology Online Journal. 2016;22(12):45-47.
Christman, Mitalee P. ; Rieder, Evan ; Kim, Randie H. ; Brinster, Nooshin ; Femia, Alisa ; Pomeranz, Miriam Keltz. / Darier-white disease. In: Dermatology Online Journal. 2016 ; Vol. 22, No. 12. pp. 45-47.
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