DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections

Anthony R. French, Hanna Sjölin, Sung Jin Kim, Rima Koka, Liping Yang, Deborah A. Young, Cristina Cerboni, Elena Tomasello, Averil Ma, Eric Vivier, Klas Kärre, Wayne M. Yokoyama

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

NK cells vigorously proliferate during viral infections. During the course of murine CMV infection, this response becomes dominated by the preferential proliferation of NK cells that express the activation receptor Ly49H. The factors driving such selective NK cell proliferation have not been characterized. In this study, we demonstrate that preferential NK cell proliferation is dependent on DAP12-mediated signaling following the binding of Ly49H to its vitally encoded ligand, m157. Ly49H signaling through DAP12 appears to directly augment NK cell sensitivity to low concentrations of proproliferative cytokines such as IL-15. The impact of Ly49H-mediated signaling on NK cell proliferation is masked in the presence of high concentrations of proproliferative cytokines that nonselectively drive all NK cells to proliferate.

Original languageEnglish (US)
Pages (from-to)4981-4990
Number of pages10
JournalJournal of Immunology
Volume177
Issue number8
StatePublished - Oct 15 2006
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    French, A. R., Sjölin, H., Kim, S. J., Koka, R., Yang, L., Young, D. A., Cerboni, C., Tomasello, E., Ma, A., Vivier, E., Kärre, K., & Yokoyama, W. M. (2006). DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections. Journal of Immunology, 177(8), 4981-4990.