Damage to tissue defenses by vasoconstrictors

Thomas R Stevenson, George T. Rodeheaver, Gerald T. Golden, Milton T. Edgerton, James H. Wells, Richard F. Edlich

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The paper investigates the effect of solutions of local anesthetic agents on the ability of wounds to resist infection as well as the influence of the injection techniques on the dissemination of bacteria through the wound. On the basis of these studies, the following recommendations are made: (1) a regional nerve block with 1% lidocaine administered through a 27 gauge needle is indicated before wound cleansing; (2) if the wound is not susceptible to a regional nerve block, anesthetize the wound by injecting the agent through the skin around the periphery of the wound; (3) avoid the use of epinephrine with the anesthetic agent.

Original languageEnglish (US)
Pages (from-to)532-535
Number of pages4
JournalJournal of the American College of Emergency Physicians
Issue number6
StatePublished - 1975
Externally publishedYes


  • anesthesia
  • epinephrine
  • lidocaine
  • vasoconstrictors
  • wound infection

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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