Daily spontaneous running alters behavioral and neurochemical indexes of nigrostriatal function

D. E. Dluzen, B. Liu, Chao-Yin Chen, S. E. DiCarlo

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Behavioral and neurochemical indexes of nigrostriatal dopaminergic function were compared between sedentary control rats (n = 12) and daily spontaneous running (DSR) male rats (n = 10). Nine weeks of DSR did not significantly alter body, heart, pituitary, or testes weights. DSR and control animals did differ in performance on a sensorimotor beam walking task, with DSR rats showing significantly shorter times required to cross the beam (60 ± 17 vs. 119 ± 14 s; P < 0.02) as well as fewer slips off the beam (3.0 ± 0.8 vs. 6.2 ± 1.1; P < 0.05). DSR animals also engaged in significantly greater durations of social investigation than control rats (43 ± 5 vs. 25 ± 3 s; P < 0.01) when tested in a social investigation memory- recognition test. Basal dopamine release rates from superfused corpus striatal tissue fragments of DSR rats were about one-half those obtained from control animals (18 ± 5 vs. 34 ± 6 pg · mg-1 · min-1; P < 0.05), whereas responses of these striatal tissue fragments to a depolarizing concentration of potassium were virtually identical (45 ± 10 vs. 47 ± 8 pg · mg-1 · min-1). These data indicate that a relatively limited intensity of DSR insufficient to alter cardiovascular function can exert substantial effects on behavioral and neurochemical indicators of nigrostriatal dopaminergic activity.

Original languageEnglish (US)
Pages (from-to)1219-1224
Number of pages6
JournalJournal of Applied Physiology
Volume78
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Running
Corpus Striatum
Walking
Testis
Dopamine
Potassium
Weights and Measures

Keywords

  • corpus striatum
  • dopamine
  • exercise
  • sensorimotor
  • social investigation

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Daily spontaneous running alters behavioral and neurochemical indexes of nigrostriatal function. / Dluzen, D. E.; Liu, B.; Chen, Chao-Yin; DiCarlo, S. E.

In: Journal of Applied Physiology, Vol. 78, No. 4, 1995, p. 1219-1224.

Research output: Contribution to journalArticle

@article{06faedd68b104d71a06bf6003c183f16,
title = "Daily spontaneous running alters behavioral and neurochemical indexes of nigrostriatal function",
abstract = "Behavioral and neurochemical indexes of nigrostriatal dopaminergic function were compared between sedentary control rats (n = 12) and daily spontaneous running (DSR) male rats (n = 10). Nine weeks of DSR did not significantly alter body, heart, pituitary, or testes weights. DSR and control animals did differ in performance on a sensorimotor beam walking task, with DSR rats showing significantly shorter times required to cross the beam (60 ± 17 vs. 119 ± 14 s; P < 0.02) as well as fewer slips off the beam (3.0 ± 0.8 vs. 6.2 ± 1.1; P < 0.05). DSR animals also engaged in significantly greater durations of social investigation than control rats (43 ± 5 vs. 25 ± 3 s; P < 0.01) when tested in a social investigation memory- recognition test. Basal dopamine release rates from superfused corpus striatal tissue fragments of DSR rats were about one-half those obtained from control animals (18 ± 5 vs. 34 ± 6 pg · mg-1 · min-1; P < 0.05), whereas responses of these striatal tissue fragments to a depolarizing concentration of potassium were virtually identical (45 ± 10 vs. 47 ± 8 pg · mg-1 · min-1). These data indicate that a relatively limited intensity of DSR insufficient to alter cardiovascular function can exert substantial effects on behavioral and neurochemical indicators of nigrostriatal dopaminergic activity.",
keywords = "corpus striatum, dopamine, exercise, sensorimotor, social investigation",
author = "Dluzen, {D. E.} and B. Liu and Chao-Yin Chen and DiCarlo, {S. E.}",
year = "1995",
language = "English (US)",
volume = "78",
pages = "1219--1224",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "4",

}

TY - JOUR

T1 - Daily spontaneous running alters behavioral and neurochemical indexes of nigrostriatal function

AU - Dluzen, D. E.

AU - Liu, B.

AU - Chen, Chao-Yin

AU - DiCarlo, S. E.

PY - 1995

Y1 - 1995

N2 - Behavioral and neurochemical indexes of nigrostriatal dopaminergic function were compared between sedentary control rats (n = 12) and daily spontaneous running (DSR) male rats (n = 10). Nine weeks of DSR did not significantly alter body, heart, pituitary, or testes weights. DSR and control animals did differ in performance on a sensorimotor beam walking task, with DSR rats showing significantly shorter times required to cross the beam (60 ± 17 vs. 119 ± 14 s; P < 0.02) as well as fewer slips off the beam (3.0 ± 0.8 vs. 6.2 ± 1.1; P < 0.05). DSR animals also engaged in significantly greater durations of social investigation than control rats (43 ± 5 vs. 25 ± 3 s; P < 0.01) when tested in a social investigation memory- recognition test. Basal dopamine release rates from superfused corpus striatal tissue fragments of DSR rats were about one-half those obtained from control animals (18 ± 5 vs. 34 ± 6 pg · mg-1 · min-1; P < 0.05), whereas responses of these striatal tissue fragments to a depolarizing concentration of potassium were virtually identical (45 ± 10 vs. 47 ± 8 pg · mg-1 · min-1). These data indicate that a relatively limited intensity of DSR insufficient to alter cardiovascular function can exert substantial effects on behavioral and neurochemical indicators of nigrostriatal dopaminergic activity.

AB - Behavioral and neurochemical indexes of nigrostriatal dopaminergic function were compared between sedentary control rats (n = 12) and daily spontaneous running (DSR) male rats (n = 10). Nine weeks of DSR did not significantly alter body, heart, pituitary, or testes weights. DSR and control animals did differ in performance on a sensorimotor beam walking task, with DSR rats showing significantly shorter times required to cross the beam (60 ± 17 vs. 119 ± 14 s; P < 0.02) as well as fewer slips off the beam (3.0 ± 0.8 vs. 6.2 ± 1.1; P < 0.05). DSR animals also engaged in significantly greater durations of social investigation than control rats (43 ± 5 vs. 25 ± 3 s; P < 0.01) when tested in a social investigation memory- recognition test. Basal dopamine release rates from superfused corpus striatal tissue fragments of DSR rats were about one-half those obtained from control animals (18 ± 5 vs. 34 ± 6 pg · mg-1 · min-1; P < 0.05), whereas responses of these striatal tissue fragments to a depolarizing concentration of potassium were virtually identical (45 ± 10 vs. 47 ± 8 pg · mg-1 · min-1). These data indicate that a relatively limited intensity of DSR insufficient to alter cardiovascular function can exert substantial effects on behavioral and neurochemical indicators of nigrostriatal dopaminergic activity.

KW - corpus striatum

KW - dopamine

KW - exercise

KW - sensorimotor

KW - social investigation

UR - http://www.scopus.com/inward/record.url?scp=0028946418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028946418&partnerID=8YFLogxK

M3 - Article

VL - 78

SP - 1219

EP - 1224

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 4

ER -