D-Aspartate potentiates the effects of L-glutamate on horizontal cells in goldfish retina

Andrew Ishida, G. L. Fain

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The amino acids L-glutamate and L-aspartate depolarize H1 horizontal cells in the perfused goldfish retina but only at millimolar concentrations. The effects of L-glutamate (but not of L-aspartate) are potentiated approximately 15-fold by exposure to D-aspartate. D-Aspartate blocks acidic amino acid uptake in goldfish retina, so that the potentiation of L-glutamate may be produced by an increase in its effective concentration at the horizontal cell membrane. Because D-asparate also augments the light responses of horizontal cells, our results are consistent with the possibility that L-glutamate is a neurotransmitter of cone photoreceptors in goldfish.

Original languageEnglish (US)
Pages (from-to)5890-5894
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume78
Issue number9 II
StatePublished - 1981
Externally publishedYes

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D-Aspartic Acid
Goldfish
Retina
Glutamic Acid
Aspartic Acid
Retinal Cone Photoreceptor Cells
Acidic Amino Acids
Neurotransmitter Agents
Cell Membrane
Light
Amino Acids

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

D-Aspartate potentiates the effects of L-glutamate on horizontal cells in goldfish retina. / Ishida, Andrew; Fain, G. L.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, No. 9 II, 1981, p. 5890-5894.

Research output: Contribution to journalArticle

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