Cytotoxic murine monoclonal antibody recognizing an ovine lymphocyte subpopulation similar to the human OKT4-positive set

G. Lalonde; Laurel J Gershwin; Peter F Moore; D. Bernoco

Cytotoxic murine monoclonal antibody recognizing an ovine lymphocyte subpopulation similar to the human OKT4-positive set

G. Lalonde, Laurel J Gershwin, Peter F Moore, D. Bernoco

Pathology, Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A cytotoxic murine immunoglobulin G2b monoclonal antibody was produced from immunization with ovine thymocytes. It reacts with a monomorphic determinant on ovine lymphocytes. This antibody 11.2 G11 does not react with B cells, lyses 50 to 60% of peripheral blood T cells, and precipitates a single chain protein with an apparent m.w. of 57,000. Its effect on mitogen- and antigen-driven lymphocyte proliferation supports its similarity in the sheep to the OKT4 antibody in humans.

Original language	English (US)
Pages (from-to)	2809-2815
Number of pages	7
Journal	Journal of Immunology
Volume	136
Issue number	8
State	Published - 1986

ASJC Scopus subject areas

Immunology

Cite this

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title = "Cytotoxic murine monoclonal antibody recognizing an ovine lymphocyte subpopulation similar to the human OKT4-positive set",

abstract = "A cytotoxic murine immunoglobulin G2b monoclonal antibody was produced from immunization with ovine thymocytes. It reacts with a monomorphic determinant on ovine lymphocytes. This antibody 11.2 G11 does not react with B cells, lyses 50 to 60% of peripheral blood T cells, and precipitates a single chain protein with an apparent m.w. of 57,000. Its effect on mitogen- and antigen-driven lymphocyte proliferation supports its similarity in the sheep to the OKT4 antibody in humans.",

author = "G. Lalonde and Gershwin, {Laurel J} and Moore, {Peter F} and D. Bernoco",

year = "1986",

language = "English (US)",

volume = "136",

pages = "2809--2815",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

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AU - Lalonde, G.

AU - Gershwin, Laurel J

AU - Moore, Peter F

AU - Bernoco, D.

PY - 1986

Y1 - 1986

N2 - A cytotoxic murine immunoglobulin G2b monoclonal antibody was produced from immunization with ovine thymocytes. It reacts with a monomorphic determinant on ovine lymphocytes. This antibody 11.2 G11 does not react with B cells, lyses 50 to 60% of peripheral blood T cells, and precipitates a single chain protein with an apparent m.w. of 57,000. Its effect on mitogen- and antigen-driven lymphocyte proliferation supports its similarity in the sheep to the OKT4 antibody in humans.

AB - A cytotoxic murine immunoglobulin G2b monoclonal antibody was produced from immunization with ovine thymocytes. It reacts with a monomorphic determinant on ovine lymphocytes. This antibody 11.2 G11 does not react with B cells, lyses 50 to 60% of peripheral blood T cells, and precipitates a single chain protein with an apparent m.w. of 57,000. Its effect on mitogen- and antigen-driven lymphocyte proliferation supports its similarity in the sheep to the OKT4 antibody in humans.

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ER -

Cytotoxic murine monoclonal antibody recognizing an ovine lymphocyte subpopulation similar to the human OKT4-positive set

Abstract

ASJC Scopus subject areas

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