Cytotoxic murine monoclonal antibody recognizing an ovine lymphocyte subpopulation similar to the human OKT4-positive set

G. Lalonde, Laurel J Gershwin, Peter F Moore, D. Bernoco

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A cytotoxic murine immunoglobulin G2b monoclonal antibody was produced from immunization with ovine thymocytes. It reacts with a monomorphic determinant on ovine lymphocytes. This antibody 11.2 G11 does not react with B cells, lyses 50 to 60% of peripheral blood T cells, and precipitates a single chain protein with an apparent m.w. of 57,000. Its effect on mitogen- and antigen-driven lymphocyte proliferation supports its similarity in the sheep to the OKT4 antibody in humans.

Original languageEnglish (US)
Pages (from-to)2809-2815
Number of pages7
JournalJournal of Immunology
Volume136
Issue number8
StatePublished - 1986

ASJC Scopus subject areas

  • Immunology

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