Abstract
A cytotoxic murine immunoglobulin G2b monoclonal antibody was produced from immunization with ovine thymocytes. It reacts with a monomorphic determinant on ovine lymphocytes. This antibody 11.2 G11 does not react with B cells, lyses 50 to 60% of peripheral blood T cells, and precipitates a single chain protein with an apparent m.w. of 57,000. Its effect on mitogen- and antigen-driven lymphocyte proliferation supports its similarity in the sheep to the OKT4 antibody in humans.
Original language | English (US) |
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Pages (from-to) | 2809-2815 |
Number of pages | 7 |
Journal | Journal of Immunology |
Volume | 136 |
Issue number | 8 |
State | Published - 1986 |
ASJC Scopus subject areas
- Immunology