Cytotoxic activity of anti theta antibody found in the γ(M) fraction

M. Eric Gershwin, T. M. Chused, A. D. Steinberg

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Abstract

It is demonstrated that the cytotoxic activity of an anti theta serum resides almost completely in the γM fraction. The antiserum titer giving 50% cytotoxicity was almost 1:1,024, whereas it was not quite 1:1 for the γG fraction. This suggested that the γM fraction was approximately 1,000 times as cytotoxic. However, the fluorescent studies did not show as great a difference. The γM fraction had a fluorescent titer of 1:16, whereas the titer of the γG fraction was 1:2. Since there was only an 8 fold difference in fluorescent titer but more than a 1,000 fold difference in cytotoxic titer, it appeared that γM anti theta was considerably more efficient than γG anti theta in effecting cytotoxicity.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalTransplantation
Volume18
Issue number4
StatePublished - 1974
Externally publishedYes

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Immune Sera
Anti-Idiotypic Antibodies
Serum

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Cytotoxic activity of anti theta antibody found in the γ(M) fraction. / Gershwin, M. Eric; Chused, T. M.; Steinberg, A. D.

In: Transplantation, Vol. 18, No. 4, 1974, p. 377-380.

Research output: Contribution to journalArticle

Gershwin, ME, Chused, TM & Steinberg, AD 1974, 'Cytotoxic activity of anti theta antibody found in the γ(M) fraction', Transplantation, vol. 18, no. 4, pp. 377-380.
Gershwin, M. Eric ; Chused, T. M. ; Steinberg, A. D. / Cytotoxic activity of anti theta antibody found in the γ(M) fraction. In: Transplantation. 1974 ; Vol. 18, No. 4. pp. 377-380.
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