Cytosolic and microsomal epoxide hydrolases: Differential properties in mammalian liver

Ota Kenji, Bruce D. Hammock

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

The epoxide hydrolase activities of the 100,000g pellet (microsomal) and 100,000g soluble (cytosolic) fractions of mouse, rat, and guinea pig liver were measured with three closely related compounds used as substrates. Differences between the species in the distribution of the cytosolic and microsomal hydrolases and in their substrate specificities and pH optima demonstrate why epoxide hydrolase activity in the cytosolic fraction was not detected earlier in spite of intensive work on the microsomal epoxide hydrolase.

Original languageEnglish (US)
Pages (from-to)1479-1481
Number of pages3
JournalScience
Volume207
Issue number4438
StatePublished - 1980

ASJC Scopus subject areas

  • General

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