Cytoskeletal Autoantibodies/Antiactin Antibodies

Christopher Aoki, Christopher L. Bowlus

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Anticytoskeleton antibodies were one of the first autoantibodies discovered, have been found in healthy individuals, and have also been associated with a number of infectious and inflammatory diseases. These autoantibodies are characterized by their binding to the principal components of microtubules, microfilaments, and intermediate filaments including actin, tubulin, keratin, vimentin, desmin, glial fibrillary acidic protein, peripherin, neurofilaments, alpha-internexin, and nuclear lamins. Given their ubiquitous presence, cytoskeletal proteins can be isolated from a number of different tissues and cells and antibodies to these antigens can be detected by a variety of methods. The mechanisms leading to the production of these autoantibodies is unclear but may be related to tissue damage and nonspecific B-cell stimulation. Thus far, anticytoskeletal antibodies have not been shown to be pathogenic and, with the exception of autoimmune hepatitis, are of limited clinical utility.

Original languageEnglish (US)
Title of host publicationAutoantibodies: Third Edition
PublisherElsevier B.V.
Pages311-317
Number of pages7
ISBN (Print)9780444563781
DOIs
StatePublished - Dec 2013

Keywords

  • Antismooth muscle antibody
  • Autoimmune hepatitis
  • Keratin
  • Microfilaments
  • Tubulin
  • Vimentin

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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  • Cite this

    Aoki, C., & Bowlus, C. L. (2013). Cytoskeletal Autoantibodies/Antiactin Antibodies. In Autoantibodies: Third Edition (pp. 311-317). Elsevier B.V.. https://doi.org/10.1016/B978-0-444-56378-1.00037-X