Anti-cytoskeleton antibodies were one of the first few autoantibodies to be discovered and have been found in a number of disease states. Further characterization of these autoantibodies has shown that these autoantibodies bind the principal components of microtubules, microfilaments, and intermediate filaments, which include actin, tubulin, keratin, vimentin, desmin, glial fibrillary acidic protein, peripherin, neurofilaments, alpha-internexin, and nuclear lamins. Because of their ubiquitous presence, cytoskeletal proteins are isolated from a number of different tissues and cells, and antibodies are detected using a variety of methods. Their significance is still under investigation but it has been suggested that they may be markers of ongoing tissue damage and non-specific B cell stimulation. Thus so far, the presence of anti-cytoskeletal antibodies has not been shown to be pathogenic and is of limited clinical utility. Although anti-cytoskeleton antibodies have been found in a number of diseases, none are pathognomic. In addition, most studies lack large numbers to determine an accurate sensitivity or specificity and therefore are not useful in clinical practice.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)