Cytomegalovirus disease of the gastrointestinal tract in patients without AIDS

Claire Pomeroy, Claire Pomeroy

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

Cytomegalovirus (CMV) infection of the gastrointestinal (GI) tract can cause serious disease in immunocompromised patients. Recipients of solid organ and bone marrow transplants, persons with malignancies, and those receiving immunosuppressive medications are at risk. When CMV infection of the GI tract causes disease, symptoms include pain, ulceration, bleeding, diarrhea, and perforation. All levels of the GI tract, from the oropharynx to the anus, may be involved Pathological examination of involved gut typically reveals diffuse ulcerations and necrosis with scattered CMV inclusions, although a variety of other abnormalities have been described. Before the introduction of antiviral therapy effective against CMV, mortality was high. However, the use of ganciclovir or foscarnet has improved the prognosis of CMV disease of the GI tract dramatically. CMV infection should be included in the differential diagnosis of GI disease in immunocompromised patients, and the clinician should pursue appropriate diagnostic and therapeutic interventions aggressively.

Original languageEnglish (US)
Pages (from-to)644-656
Number of pages13
JournalClinical Infectious Diseases
Volume17
Issue number4
StatePublished - Oct 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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