Cytomegalovirus (CMV) polymerase chain reaction profiles in individuals with advanced human immunodeficiency virus infection: Relationship to CMV disease

Mostafa A. Nokta, Fiona Holland, Victor De Gruttola, Vincent C. Emery, Mark A. Jacobson, Paul Griffiths, Richard B Pollard, Judith E. Feinberg

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) disease is a common complication of patients with advanced human immunodeficiency virus infection. The aim of the present study, based on a case-cohort design, was to determine the predictive value of follow-up and baseline qualitative plasma CMV polymerase chain reaction (PCR) values for CMV end-organ disease in 378 patients (158 who progressed to CMV end-organ disease and 220 who did not develop CMV disease). These patients are part of the full AIDS Clinical Trials Group 204 multinational study (1227 patients), a randomized, controlled trial that compared the effects of valacyclovir with those of acyclovir for CMV disease prevention. Baseline PCR positivity was a significant risk factor for CMV disease progression (relative risk [RR], 1.81; 95% confidence interval [CI], 1.09-3.00). In multivariate analyses, time-updated PCR positivity was strongly associated with progression to CMV end-organ disease (RR, 4.42; 95% CI, 2.87-6.81). Change in cumulative PCR status was informative for the risk of subsequent CMV disease.

Original languageEnglish (US)
Pages (from-to)1717-1722
Number of pages6
JournalJournal of Infectious Diseases
Volume185
Issue number12
DOIs
StatePublished - Jun 15 2002
Externally publishedYes

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Virus Diseases
Cytomegalovirus
HIV
Polymerase Chain Reaction
valacyclovir
Confidence Intervals
Acyclovir
Disease Progression
Acquired Immunodeficiency Syndrome
Multivariate Analysis
Randomized Controlled Trials
Clinical Trials

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Nokta, M. A., Holland, F., De Gruttola, V., Emery, V. C., Jacobson, M. A., Griffiths, P., ... Feinberg, J. E. (2002). Cytomegalovirus (CMV) polymerase chain reaction profiles in individuals with advanced human immunodeficiency virus infection: Relationship to CMV disease. Journal of Infectious Diseases, 185(12), 1717-1722. https://doi.org/10.1086/340651

Cytomegalovirus (CMV) polymerase chain reaction profiles in individuals with advanced human immunodeficiency virus infection : Relationship to CMV disease. / Nokta, Mostafa A.; Holland, Fiona; De Gruttola, Victor; Emery, Vincent C.; Jacobson, Mark A.; Griffiths, Paul; Pollard, Richard B; Feinberg, Judith E.

In: Journal of Infectious Diseases, Vol. 185, No. 12, 15.06.2002, p. 1717-1722.

Research output: Contribution to journalArticle

Nokta, Mostafa A. ; Holland, Fiona ; De Gruttola, Victor ; Emery, Vincent C. ; Jacobson, Mark A. ; Griffiths, Paul ; Pollard, Richard B ; Feinberg, Judith E. / Cytomegalovirus (CMV) polymerase chain reaction profiles in individuals with advanced human immunodeficiency virus infection : Relationship to CMV disease. In: Journal of Infectious Diseases. 2002 ; Vol. 185, No. 12. pp. 1717-1722.
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