Abstract
Cytomegalovirus (CMV) disease is a common complication of patients with advanced human immunodeficiency virus infection. The aim of the present study, based on a case-cohort design, was to determine the predictive value of follow-up and baseline qualitative plasma CMV polymerase chain reaction (PCR) values for CMV end-organ disease in 378 patients (158 who progressed to CMV end-organ disease and 220 who did not develop CMV disease). These patients are part of the full AIDS Clinical Trials Group 204 multinational study (1227 patients), a randomized, controlled trial that compared the effects of valacyclovir with those of acyclovir for CMV disease prevention. Baseline PCR positivity was a significant risk factor for CMV disease progression (relative risk [RR], 1.81; 95% confidence interval [CI], 1.09-3.00). In multivariate analyses, time-updated PCR positivity was strongly associated with progression to CMV end-organ disease (RR, 4.42; 95% CI, 2.87-6.81). Change in cumulative PCR status was informative for the risk of subsequent CMV disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1717-1722 |
| Number of pages | 6 |
| Journal | Journal of Infectious Diseases |
| Volume | 185 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jun 15 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
Cite this
Cytomegalovirus (CMV) polymerase chain reaction profiles in individuals with advanced human immunodeficiency virus infection : Relationship to CMV disease. / Nokta, Mostafa A.; Holland, Fiona; De Gruttola, Victor; Emery, Vincent C.; Jacobson, Mark A.; Griffiths, Paul; Pollard, Richard B; Feinberg, Judith E.
In: Journal of Infectious Diseases, Vol. 185, No. 12, 15.06.2002, p. 1717-1722.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytomegalovirus (CMV) polymerase chain reaction profiles in individuals with advanced human immunodeficiency virus infection
T2 - Relationship to CMV disease
AU - Nokta, Mostafa A.
AU - Holland, Fiona
AU - De Gruttola, Victor
AU - Emery, Vincent C.
AU - Jacobson, Mark A.
AU - Griffiths, Paul
AU - Pollard, Richard B
AU - Feinberg, Judith E.
PY - 2002/6/15
Y1 - 2002/6/15
N2 - Cytomegalovirus (CMV) disease is a common complication of patients with advanced human immunodeficiency virus infection. The aim of the present study, based on a case-cohort design, was to determine the predictive value of follow-up and baseline qualitative plasma CMV polymerase chain reaction (PCR) values for CMV end-organ disease in 378 patients (158 who progressed to CMV end-organ disease and 220 who did not develop CMV disease). These patients are part of the full AIDS Clinical Trials Group 204 multinational study (1227 patients), a randomized, controlled trial that compared the effects of valacyclovir with those of acyclovir for CMV disease prevention. Baseline PCR positivity was a significant risk factor for CMV disease progression (relative risk [RR], 1.81; 95% confidence interval [CI], 1.09-3.00). In multivariate analyses, time-updated PCR positivity was strongly associated with progression to CMV end-organ disease (RR, 4.42; 95% CI, 2.87-6.81). Change in cumulative PCR status was informative for the risk of subsequent CMV disease.
AB - Cytomegalovirus (CMV) disease is a common complication of patients with advanced human immunodeficiency virus infection. The aim of the present study, based on a case-cohort design, was to determine the predictive value of follow-up and baseline qualitative plasma CMV polymerase chain reaction (PCR) values for CMV end-organ disease in 378 patients (158 who progressed to CMV end-organ disease and 220 who did not develop CMV disease). These patients are part of the full AIDS Clinical Trials Group 204 multinational study (1227 patients), a randomized, controlled trial that compared the effects of valacyclovir with those of acyclovir for CMV disease prevention. Baseline PCR positivity was a significant risk factor for CMV disease progression (relative risk [RR], 1.81; 95% confidence interval [CI], 1.09-3.00). In multivariate analyses, time-updated PCR positivity was strongly associated with progression to CMV end-organ disease (RR, 4.42; 95% CI, 2.87-6.81). Change in cumulative PCR status was informative for the risk of subsequent CMV disease.
UR - http://www.scopus.com/inward/record.url?scp=0037097541&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037097541&partnerID=8YFLogxK
U2 - 10.1086/340651
DO - 10.1086/340651
M3 - Article
C2 - 12085316
AN - SCOPUS:0037097541
VL - 185
SP - 1717
EP - 1722
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 12
ER -