Cytomegalovirus and simian immunodeficiency virus coinfection

Longitudinal study of antibody responses and disease progression

Silvia Baroncelli, Peter A Barry, John P. Capitanio, Nicholas W. Lerche, Moses Otsyula, Sally P. Mendoza

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Antibody liters to rhesus cytomegalovirus (RhCMV) were prospectively analyzed over a period of 68 weeks in a longitudinal serosurvey of 17 RhCMV- seropositive rhesus macaques (Macaca mullata) experimentally coinfected with simian immunodeficiency virus (SIV). These were compared with anti-RhCMV titers in 18 animals that were also naturally infected with RhCMV but not infected with SIV. Fluctuations in anti-RhCMV antibody tilers were observed within 5 weeks of SIV inoculation, and two distinct patterns of RhCMV antibody response were observed in SIV-infected animals. Animals showing a progressive decline in anti-RhCMV immunoglobulin G (IgG) exhibited the most rapid disease progression, coincident with low anti-SIV and anti-tetanus toxoid IgG responses, high levels of p27 antigen in the plasma, and short survival. Animals exhibiting a more stable CMV-specific response after SIV inoculation had the least rapid disease course. Anti-RhCMV antibody liters in SIV-uninfected animals remained relatively stable during the period of study. Evidence that preinoculation immunologic measures predicted postinoculation outcome was equivocal.

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume15
Issue number1
StatePublished - May 1 1997

Fingerprint

Simian Immunodeficiency Virus
Cytomegalovirus
Coinfection
Antibody Formation
Longitudinal Studies
Disease Progression
Antibodies
Immunoglobulin G
Tetanus Toxoid
Macaca
Macaca mulatta

Keywords

  • Cofactors
  • Cytomegalovirus
  • Nonhuman primate model
  • Serology
  • SIV
  • Tetanus toxoid

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

Cytomegalovirus and simian immunodeficiency virus coinfection : Longitudinal study of antibody responses and disease progression. / Baroncelli, Silvia; Barry, Peter A; Capitanio, John P.; Lerche, Nicholas W.; Otsyula, Moses; Mendoza, Sally P.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 15, No. 1, 01.05.1997, p. 5-15.

Research output: Contribution to journalArticle

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