Cytomegalovirus and simian immunodeficiency virus coinfection: Longitudinal study of antibody responses and disease progression

Silvia Baroncelli, Peter A Barry, John P. Capitanio, Nicholas W. Lerche, Moses Otsyula, Sally P. Mendoza

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Antibody liters to rhesus cytomegalovirus (RhCMV) were prospectively analyzed over a period of 68 weeks in a longitudinal serosurvey of 17 RhCMV- seropositive rhesus macaques (Macaca mullata) experimentally coinfected with simian immunodeficiency virus (SIV). These were compared with anti-RhCMV titers in 18 animals that were also naturally infected with RhCMV but not infected with SIV. Fluctuations in anti-RhCMV antibody tilers were observed within 5 weeks of SIV inoculation, and two distinct patterns of RhCMV antibody response were observed in SIV-infected animals. Animals showing a progressive decline in anti-RhCMV immunoglobulin G (IgG) exhibited the most rapid disease progression, coincident with low anti-SIV and anti-tetanus toxoid IgG responses, high levels of p27 antigen in the plasma, and short survival. Animals exhibiting a more stable CMV-specific response after SIV inoculation had the least rapid disease course. Anti-RhCMV antibody liters in SIV-uninfected animals remained relatively stable during the period of study. Evidence that preinoculation immunologic measures predicted postinoculation outcome was equivocal.

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume15
Issue number1
StatePublished - May 1 1997

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Keywords

  • Cofactors
  • Cytomegalovirus
  • Nonhuman primate model
  • Serology
  • SIV
  • Tetanus toxoid

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

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