Cytological studies of recombination in rhesus males

T. Hassold, T. Hansen, P. Hunt, C. Vandevoort

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

An immunofluorescence approach was used to directly examine meiotic recombination events in 483 pachytene spermatocytes from 11 male rhesus monkeys. Specifically, we examined the nuclear localization patterns of the DNA mismatch repair protein MLH1, known from analyses of other mammalian species to be a useful marker of meiotic cross-overs. Our results indicated that rhesus pachytene spermatocytes contain approximately 40 cross-overs per cell, corresponding to about one cross-over per chromosome. The chromosomal distribution of these exchanges was consistent with data from human and mouse males but, surprisingly, the overall number of foci was lower, and the number of 'exchangeless' bivalents higher, than reported for either humans or mice.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalCytogenetic and Genome Research
Volume124
Issue number2
DOIs
StatePublished - May 2009

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

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