TY - JOUR
T1 - Cytokinocytes
T2 - The diverse contribution of keratinocytes to immune responses in skin
AU - Jiang, Yanyun
AU - Tsoi, Lam C.
AU - Billi, Allison C.
AU - Ward, Nicole L.
AU - Harms, Paul W.
AU - Zeng, Chang
AU - Maverakis, Emanual
AU - Michelle Kahlenberg, J.
AU - Gudjonsson, Johann E.
N1 - Funding Information:
This work was supported by the Babcock Endowment Fund (to LCT and JEG), the A. Alfred Taubman Medical Research Institute (to JEG and JMK), and the Parfet Emerging Scholar Award (to JMK). Additional support came from the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the NIH under award numbers R01-AR069071, R01-AI130025, and P30-AR075043 (to JEG); P30-AR39750, P50-AR055508, P50-AR070590, R01-AR063437, R01-AR062546, and R21-AR063852 (to NLW); K01-AR072129 (to LCT); R01-AR069071 and R01-AR073196 (to JEG and NLW); and T32-AR007197 (to ACB). LCT, NLW, and JEG have all received support from the Dermatology Foundation, the National Psoriasis Foundation, and the Arthritis National Research Foundation.
PY - 2020/10/15
Y1 - 2020/10/15
N2 - The skin serves as the primary interface between our body and the external environment and acts as a barrier against entry of physical agents, chemicals, and microbes. Keratinocytes make up the main cellular constitute of the outermost layer of the skin, contributing to the formation of the epidermis, and they are crucial for maintaining the integrity of this barrier. Beyond serving as a physical barrier component, keratinocytes actively participate in maintaining tissue homeostasis, shaping, amplifying, and regulating immune responses in skin. Keratinocytes act as sentinels, continuously monitoring changes in the environment, and, through microbial sensing, stretch, or other physical stimuli, can initiate a broad range of inflammatory responses via secretion of various cytokines, chemokines, and growth factors. This diverse function of keratinocytes contributes to the highly variable clinical manifestation of skin immune responses. In this Review, we highlight the highly diverse functions of epidermal keratinocytes and their contribution to various immune-mediated skin diseases.
AB - The skin serves as the primary interface between our body and the external environment and acts as a barrier against entry of physical agents, chemicals, and microbes. Keratinocytes make up the main cellular constitute of the outermost layer of the skin, contributing to the formation of the epidermis, and they are crucial for maintaining the integrity of this barrier. Beyond serving as a physical barrier component, keratinocytes actively participate in maintaining tissue homeostasis, shaping, amplifying, and regulating immune responses in skin. Keratinocytes act as sentinels, continuously monitoring changes in the environment, and, through microbial sensing, stretch, or other physical stimuli, can initiate a broad range of inflammatory responses via secretion of various cytokines, chemokines, and growth factors. This diverse function of keratinocytes contributes to the highly variable clinical manifestation of skin immune responses. In this Review, we highlight the highly diverse functions of epidermal keratinocytes and their contribution to various immune-mediated skin diseases.
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U2 - 10.1172/jci.insight.142067
DO - 10.1172/jci.insight.142067
M3 - Review article
C2 - 33055429
AN - SCOPUS:85093485290
VL - 5
JO - JCI insight
JF - JCI insight
SN - 2379-3708
IS - 20
M1 - e142067
ER -