Abstract
Although the portal circulation exposes the liver to a host of non-self-antigens originating from alimentation and commensal bacteria, these components do not mount an immune response under homeostatic conditions. However, the liver is also the site where hepatotropic infections could potentially set in and the ability to tune the delicate balance between tolerogenic and immunogenic mechanisms is a key feature of liver physiology. Dysregulation in any of these mechanisms can result in disease including autoimmunity or persistence of viral infections. These immunological mechanisms also govern the wound healing processes that result in fibrogenesis and cirrhosis-a common end result of many of the chronic liver pathologies. Cytokines constitute the mechanistic platform upon which these processes operate, and orchestrate that fine tuning which is crucial for liver health.
| Original language | English (US) |
|---|---|
| Title of host publication | Cytokine Effector Functions in Tissues |
| Publisher | Elsevier Inc. |
| Pages | 75-96 |
| Number of pages | 22 |
| ISBN (Electronic) | 9780128042199 |
| ISBN (Print) | 9780128042144 |
| DOIs | |
| State | Published - Jan 1 2017 |
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Keywords
- Cirrhosis
- Live immunology
- Liver tolerance
- Steatohepatitis
- Viral hepatitis
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
Cite this
Cytokines in the Liver : Cytokine Mechanisms in Liver Health and Disease. / Mousa, Hani S.; Bernuzzi, Francesca; Invernizzi, Pietro.
Cytokine Effector Functions in Tissues. Elsevier Inc., 2017. p. 75-96.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Cytokines in the Liver
T2 - Cytokine Mechanisms in Liver Health and Disease
AU - Mousa, Hani S.
AU - Bernuzzi, Francesca
AU - Invernizzi, Pietro
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Although the portal circulation exposes the liver to a host of non-self-antigens originating from alimentation and commensal bacteria, these components do not mount an immune response under homeostatic conditions. However, the liver is also the site where hepatotropic infections could potentially set in and the ability to tune the delicate balance between tolerogenic and immunogenic mechanisms is a key feature of liver physiology. Dysregulation in any of these mechanisms can result in disease including autoimmunity or persistence of viral infections. These immunological mechanisms also govern the wound healing processes that result in fibrogenesis and cirrhosis-a common end result of many of the chronic liver pathologies. Cytokines constitute the mechanistic platform upon which these processes operate, and orchestrate that fine tuning which is crucial for liver health.
AB - Although the portal circulation exposes the liver to a host of non-self-antigens originating from alimentation and commensal bacteria, these components do not mount an immune response under homeostatic conditions. However, the liver is also the site where hepatotropic infections could potentially set in and the ability to tune the delicate balance between tolerogenic and immunogenic mechanisms is a key feature of liver physiology. Dysregulation in any of these mechanisms can result in disease including autoimmunity or persistence of viral infections. These immunological mechanisms also govern the wound healing processes that result in fibrogenesis and cirrhosis-a common end result of many of the chronic liver pathologies. Cytokines constitute the mechanistic platform upon which these processes operate, and orchestrate that fine tuning which is crucial for liver health.
KW - Cirrhosis
KW - Live immunology
KW - Liver tolerance
KW - Steatohepatitis
KW - Viral hepatitis
UR - http://www.scopus.com/inward/record.url?scp=85032149359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032149359&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-804214-4.00003-8
DO - 10.1016/B978-0-12-804214-4.00003-8
M3 - Chapter
AN - SCOPUS:85032149359
SN - 9780128042144
SP - 75
EP - 96
BT - Cytokine Effector Functions in Tissues
PB - Elsevier Inc.
ER -