Cytokine production by blue tongue virus-infected fetal sheep cells

F. M. Enright, Bennie Osburn

Research output: Contribution to journalArticlepeer-review


The migration inhibition of guinea pig peritoneal macrophages by a factor(s) from media obtained from blue tongue virus-infected monolayer cultures was studied. Medium from blue tongue virus-infected sheep fetal cell cultures inhibited migration of guinea pig macrophages from agarose droplets. Medium from control cultures and stock virus did not inhibit macrophage migration. Medium containing migration inhibiting factor(s) in vitro induced an inflammatory reaction in the skin of a newborn sheep. The inflammatory reaction was observed 20 h after intradermal inoculation. The skin reaction consisted of infiltrates of mononuclear leukocytes in the superficial dermis. Control medium and stock virus caused no skin reaction.

Original languageEnglish (US)
Pages (from-to)403-407
Number of pages5
JournalInfection and Immunity
Issue number1
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • Immunology


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