Abstract
The human immunodeficiency virus establishes an intimate interaction with the immune system. The virus can use cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1 (Il-1), to regulate its own expression by modifying the normal immunoregulatory network. We demonstrate that mRNA of the cytokine TNF-α from peripheral blood mononuclear cells is overexpressed in virtually all patients with AIDS who do not have active opportunistic infections compared with uninfected volunteers (p < 0.0001). This overexpression correlates with elevated mRNA levels of the recently discovered GRO (p < 0.05), a cytokine involved in the inflammatory response.
Original language | English (US) |
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Pages (from-to) | 1099-1104 |
Number of pages | 6 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 5 |
Issue number | 11 |
State | Published - 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- Virology
- Immunology and Allergy