Cytokine dysregulation in AIDS: In vivo overexpression of mRNA of tumor necrosis factor-α and its correlation with that of the inflammatory cytokine GRO

B. J. Dezube, A. B. Pardee, Laurel A Beckett, C. M. Ahlers, L. Ecto, J. Allen-Ryan, A. Anisowicz, R. Sager, C. S. Crumpacker

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

The human immunodeficiency virus establishes an intimate interaction with the immune system. The virus can use cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1 (Il-1), to regulate its own expression by modifying the normal immunoregulatory network. We demonstrate that mRNA of the cytokine TNF-α from peripheral blood mononuclear cells is overexpressed in virtually all patients with AIDS who do not have active opportunistic infections compared with uninfected volunteers (p < 0.0001). This overexpression correlates with elevated mRNA levels of the recently discovered GRO (p < 0.05), a cytokine involved in the inflammatory response.

Original languageEnglish (US)
Pages (from-to)1099-1104
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume5
Issue number11
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Virology
  • Immunology and Allergy

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