Cytokine dysregulation in AIDS: In vivo overexpression of mRNA of tumor necrosis factor-α and its correlation with that of the inflammatory cytokine GRO

B. J. Dezube, A. B. Pardee, Laurel A Beckett, C. M. Ahlers, L. Ecto, J. Allen-Ryan, A. Anisowicz, R. Sager, C. S. Crumpacker

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The human immunodeficiency virus establishes an intimate interaction with the immune system. The virus can use cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1 (Il-1), to regulate its own expression by modifying the normal immunoregulatory network. We demonstrate that mRNA of the cytokine TNF-α from peripheral blood mononuclear cells is overexpressed in virtually all patients with AIDS who do not have active opportunistic infections compared with uninfected volunteers (p < 0.0001). This overexpression correlates with elevated mRNA levels of the recently discovered GRO (p < 0.05), a cytokine involved in the inflammatory response.

Original languageEnglish (US)
Pages (from-to)1099-1104
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume5
Issue number11
StatePublished - 1992
Externally publishedYes

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Acquired Immunodeficiency Syndrome
Tumor Necrosis Factor-alpha
Cytokines
Messenger RNA
Opportunistic Infections
Interleukin-1
Volunteers
Immune System
Blood Cells
HIV
Viruses

ASJC Scopus subject areas

  • Virology
  • Immunology and Allergy

Cite this

Cytokine dysregulation in AIDS : In vivo overexpression of mRNA of tumor necrosis factor-α and its correlation with that of the inflammatory cytokine GRO. / Dezube, B. J.; Pardee, A. B.; Beckett, Laurel A; Ahlers, C. M.; Ecto, L.; Allen-Ryan, J.; Anisowicz, A.; Sager, R.; Crumpacker, C. S.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 5, No. 11, 1992, p. 1099-1104.

Research output: Contribution to journalArticle

Dezube, BJ, Pardee, AB, Beckett, LA, Ahlers, CM, Ecto, L, Allen-Ryan, J, Anisowicz, A, Sager, R & Crumpacker, CS 1992, 'Cytokine dysregulation in AIDS: In vivo overexpression of mRNA of tumor necrosis factor-α and its correlation with that of the inflammatory cytokine GRO', Journal of Acquired Immune Deficiency Syndromes, vol. 5, no. 11, pp. 1099-1104.
Dezube, B. J. ; Pardee, A. B. ; Beckett, Laurel A ; Ahlers, C. M. ; Ecto, L. ; Allen-Ryan, J. ; Anisowicz, A. ; Sager, R. ; Crumpacker, C. S. / Cytokine dysregulation in AIDS : In vivo overexpression of mRNA of tumor necrosis factor-α and its correlation with that of the inflammatory cytokine GRO. In: Journal of Acquired Immune Deficiency Syndromes. 1992 ; Vol. 5, No. 11. pp. 1099-1104.
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AU - Ahlers, C. M.

AU - Ecto, L.

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