Abstract
The human immunodeficiency virus establishes an intimate interaction with the immune system. The virus can use cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1 (Il-1), to regulate its own expression by modifying the normal immunoregulatory network. We demonstrate that mRNA of the cytokine TNF-α from peripheral blood mononuclear cells is overexpressed in virtually all patients with AIDS who do not have active opportunistic infections compared with uninfected volunteers (p < 0.0001). This overexpression correlates with elevated mRNA levels of the recently discovered GRO (p < 0.05), a cytokine involved in the inflammatory response.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1099-1104 |
| Number of pages | 6 |
| Journal | Journal of Acquired Immune Deficiency Syndromes |
| Volume | 5 |
| Issue number | 11 |
| State | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Virology
- Immunology and Allergy
Cite this
Cytokine dysregulation in AIDS : In vivo overexpression of mRNA of tumor necrosis factor-α and its correlation with that of the inflammatory cytokine GRO. / Dezube, B. J.; Pardee, A. B.; Beckett, Laurel A; Ahlers, C. M.; Ecto, L.; Allen-Ryan, J.; Anisowicz, A.; Sager, R.; Crumpacker, C. S.
In: Journal of Acquired Immune Deficiency Syndromes, Vol. 5, No. 11, 1992, p. 1099-1104.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytokine dysregulation in AIDS
T2 - In vivo overexpression of mRNA of tumor necrosis factor-α and its correlation with that of the inflammatory cytokine GRO
AU - Dezube, B. J.
AU - Pardee, A. B.
AU - Beckett, Laurel A
AU - Ahlers, C. M.
AU - Ecto, L.
AU - Allen-Ryan, J.
AU - Anisowicz, A.
AU - Sager, R.
AU - Crumpacker, C. S.
PY - 1992
Y1 - 1992
N2 - The human immunodeficiency virus establishes an intimate interaction with the immune system. The virus can use cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1 (Il-1), to regulate its own expression by modifying the normal immunoregulatory network. We demonstrate that mRNA of the cytokine TNF-α from peripheral blood mononuclear cells is overexpressed in virtually all patients with AIDS who do not have active opportunistic infections compared with uninfected volunteers (p < 0.0001). This overexpression correlates with elevated mRNA levels of the recently discovered GRO (p < 0.05), a cytokine involved in the inflammatory response.
AB - The human immunodeficiency virus establishes an intimate interaction with the immune system. The virus can use cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1 (Il-1), to regulate its own expression by modifying the normal immunoregulatory network. We demonstrate that mRNA of the cytokine TNF-α from peripheral blood mononuclear cells is overexpressed in virtually all patients with AIDS who do not have active opportunistic infections compared with uninfected volunteers (p < 0.0001). This overexpression correlates with elevated mRNA levels of the recently discovered GRO (p < 0.05), a cytokine involved in the inflammatory response.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026453101&partnerID=8YFLogxK
M3 - Article
C2 - 1403638
AN - SCOPUS:0026453101
VL - 5
SP - 1099
EP - 1104
JO - Journal of acquired immune deficiency syndromes (1999)
JF - Journal of acquired immune deficiency syndromes (1999)
SN - 1525-4135
IS - 11
ER -