Cytokine clearances in critically ill patients on continuous renal replacement therapy

Ling-Xin Chen, Sevag Demirjian, Suneel M. Udani, Sharon A. Trevino, Patrick T. Murray, Jay L. Koyner

    Research output: Contribution to journalArticle

    Abstract

    Background/Aims: We sought to quantify any differences in cytokine clearance between continuous venovenous hemofiltration (CVVH-convective) compared to continuous venovenous hemodialysis (CVVHD-diffusive). Methods: We conducted a 20 patient, multicenter, prospective, open-label randomized trial (CVVH or CVVHD) at continuous renal -replacement therapy (CRRT) initiation. Blood, urine, and effluent were collected at 0, 4, 24, and 48 h after initiation of CRRT. Serum electrolytes, cytokines levels, and clearances were measured. Cytokines studies included IL-1β, IL-1RA, IL-6, IL-10, and TNFα. Results: We randomized 20 patients to receive CRRT. After 4 h of CRRT there was no difference in total cytokine levels or change in cytokine concentrations across the 2 groups. With the exception of IL-1 RA, all cytokines levels decreased across patient groups regardless of modality. There was no significant difference in cytokine concentration across CRRT modality for any time point. Conclusion: Within the first 4 h of CRRT initiation, there is no significant difference between cytokine or solute clearance between CVVH and CVVHD.

    Original languageEnglish (US)
    Pages (from-to)315-322
    Number of pages8
    JournalBlood Purification
    Volume46
    Issue number4
    DOIs
    StatePublished - Oct 1 2018

    Fingerprint

    Renal Replacement Therapy
    Critical Illness
    Cytokines
    Interleukin-1
    Hemofiltration
    Interleukin-10
    Electrolytes
    Renal Dialysis
    Interleukin-6
    Urine
    Serum

    Keywords

    • Acute kidney injury
    • Continuous renal replacement therapy
    • Cytokines
    • Interleukin-1beta
    • Interleukin-6
    • Tumor necrosis factor

    ASJC Scopus subject areas

    • Hematology
    • Nephrology

    Cite this

    Chen, L-X., Demirjian, S., Udani, S. M., Trevino, S. A., Murray, P. T., & Koyner, J. L. (2018). Cytokine clearances in critically ill patients on continuous renal replacement therapy. Blood Purification, 46(4), 315-322. https://doi.org/10.1159/000492025

    Cytokine clearances in critically ill patients on continuous renal replacement therapy. / Chen, Ling-Xin; Demirjian, Sevag; Udani, Suneel M.; Trevino, Sharon A.; Murray, Patrick T.; Koyner, Jay L.

    In: Blood Purification, Vol. 46, No. 4, 01.10.2018, p. 315-322.

    Research output: Contribution to journalArticle

    Chen, L-X, Demirjian, S, Udani, SM, Trevino, SA, Murray, PT & Koyner, JL 2018, 'Cytokine clearances in critically ill patients on continuous renal replacement therapy', Blood Purification, vol. 46, no. 4, pp. 315-322. https://doi.org/10.1159/000492025
    Chen, Ling-Xin ; Demirjian, Sevag ; Udani, Suneel M. ; Trevino, Sharon A. ; Murray, Patrick T. ; Koyner, Jay L. / Cytokine clearances in critically ill patients on continuous renal replacement therapy. In: Blood Purification. 2018 ; Vol. 46, No. 4. pp. 315-322.
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