Cytokine clearances in critically ill patients on continuous renal replacement therapy

Ling Xin Chen, Sevag Demirjian, Suneel M. Udani, Sharon A. Trevino, Patrick T. Murray, Jay L. Koyner

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    Background/Aims: We sought to quantify any differences in cytokine clearance between continuous venovenous hemofiltration (CVVH-convective) compared to continuous venovenous hemodialysis (CVVHD-diffusive). Methods: We conducted a 20 patient, multicenter, prospective, open-label randomized trial (CVVH or CVVHD) at continuous renal -replacement therapy (CRRT) initiation. Blood, urine, and effluent were collected at 0, 4, 24, and 48 h after initiation of CRRT. Serum electrolytes, cytokines levels, and clearances were measured. Cytokines studies included IL-1β, IL-1RA, IL-6, IL-10, and TNFα. Results: We randomized 20 patients to receive CRRT. After 4 h of CRRT there was no difference in total cytokine levels or change in cytokine concentrations across the 2 groups. With the exception of IL-1 RA, all cytokines levels decreased across patient groups regardless of modality. There was no significant difference in cytokine concentration across CRRT modality for any time point. Conclusion: Within the first 4 h of CRRT initiation, there is no significant difference between cytokine or solute clearance between CVVH and CVVHD.

    Original languageEnglish (US)
    Pages (from-to)315-322
    Number of pages8
    JournalBlood Purification
    Volume46
    Issue number4
    DOIs
    StatePublished - Oct 1 2018

    Keywords

    • Acute kidney injury
    • Continuous renal replacement therapy
    • Cytokines
    • Interleukin-1beta
    • Interleukin-6
    • Tumor necrosis factor

    ASJC Scopus subject areas

    • Hematology
    • Nephrology

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