Cystic fibrosis in adults from researcher to practitioner

Gregory P. Marelich, Carroll E Cross

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The Cystic Fibrosis Foundation currently tracks about 20,000 Americans with cystic fibrosis, an autosomal recessive genetic disease that leads to multisystem complications. With the institution of better therapeutic regimens over the past 2 decades, more patients with this disease are surviving to adulthood. Within the past decade, both clinical and basic science research in the field of cystic fibro-sis has progressed at a rapid rate. The intent of this review is to introduce readers to the molecular, cellular, and systemic disorders of this disease. We discuss treatment strategies involving antibiotics, nutrition, immune-response mediators, chest physiotherapy, and sputum-active agents with respect to the airway dysfunction of cystic fibrosis. Other common complications, recent developments, transplantation, and gene therapy are also reviewed.

Original languageEnglish (US)
Pages (from-to)321-334
Number of pages14
JournalWestern Journal of Medicine
Volume164
Issue number4
StatePublished - Apr 1996

ASJC Scopus subject areas

  • Medicine(all)

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