Cystic fibrosis in adults from researcher to practitioner

Gregory P. Marelich, Carroll E Cross

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The Cystic Fibrosis Foundation currently tracks about 20,000 Americans with cystic fibrosis, an autosomal recessive genetic disease that leads to multisystem complications. With the institution of better therapeutic regimens over the past 2 decades, more patients with this disease are surviving to adulthood. Within the past decade, both clinical and basic science research in the field of cystic fibro-sis has progressed at a rapid rate. The intent of this review is to introduce readers to the molecular, cellular, and systemic disorders of this disease. We discuss treatment strategies involving antibiotics, nutrition, immune-response mediators, chest physiotherapy, and sputum-active agents with respect to the airway dysfunction of cystic fibrosis. Other common complications, recent developments, transplantation, and gene therapy are also reviewed.

Original languageEnglish (US)
Pages (from-to)321-334
Number of pages14
JournalWestern Journal of Medicine
Volume164
Issue number4
StatePublished - Apr 1996

Fingerprint

Cystic Fibrosis
Research Personnel
Inborn Genetic Diseases
Sputum
Genetic Therapy
Thorax
Transplantation
Anti-Bacterial Agents
Therapeutics
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cystic fibrosis in adults from researcher to practitioner. / Marelich, Gregory P.; Cross, Carroll E.

In: Western Journal of Medicine, Vol. 164, No. 4, 04.1996, p. 321-334.

Research output: Contribution to journalArticle

@article{434621aecf94424f9bef14fa6ec9ebe7,
title = "Cystic fibrosis in adults from researcher to practitioner",
abstract = "The Cystic Fibrosis Foundation currently tracks about 20,000 Americans with cystic fibrosis, an autosomal recessive genetic disease that leads to multisystem complications. With the institution of better therapeutic regimens over the past 2 decades, more patients with this disease are surviving to adulthood. Within the past decade, both clinical and basic science research in the field of cystic fibro-sis has progressed at a rapid rate. The intent of this review is to introduce readers to the molecular, cellular, and systemic disorders of this disease. We discuss treatment strategies involving antibiotics, nutrition, immune-response mediators, chest physiotherapy, and sputum-active agents with respect to the airway dysfunction of cystic fibrosis. Other common complications, recent developments, transplantation, and gene therapy are also reviewed.",
author = "Marelich, {Gregory P.} and Cross, {Carroll E}",
year = "1996",
month = "4",
language = "English (US)",
volume = "164",
pages = "321--334",
journal = "Western Journal of Medicine",
issn = "0093-0415",
publisher = "BMJ Publishing Group",
number = "4",

}

TY - JOUR

T1 - Cystic fibrosis in adults from researcher to practitioner

AU - Marelich, Gregory P.

AU - Cross, Carroll E

PY - 1996/4

Y1 - 1996/4

N2 - The Cystic Fibrosis Foundation currently tracks about 20,000 Americans with cystic fibrosis, an autosomal recessive genetic disease that leads to multisystem complications. With the institution of better therapeutic regimens over the past 2 decades, more patients with this disease are surviving to adulthood. Within the past decade, both clinical and basic science research in the field of cystic fibro-sis has progressed at a rapid rate. The intent of this review is to introduce readers to the molecular, cellular, and systemic disorders of this disease. We discuss treatment strategies involving antibiotics, nutrition, immune-response mediators, chest physiotherapy, and sputum-active agents with respect to the airway dysfunction of cystic fibrosis. Other common complications, recent developments, transplantation, and gene therapy are also reviewed.

AB - The Cystic Fibrosis Foundation currently tracks about 20,000 Americans with cystic fibrosis, an autosomal recessive genetic disease that leads to multisystem complications. With the institution of better therapeutic regimens over the past 2 decades, more patients with this disease are surviving to adulthood. Within the past decade, both clinical and basic science research in the field of cystic fibro-sis has progressed at a rapid rate. The intent of this review is to introduce readers to the molecular, cellular, and systemic disorders of this disease. We discuss treatment strategies involving antibiotics, nutrition, immune-response mediators, chest physiotherapy, and sputum-active agents with respect to the airway dysfunction of cystic fibrosis. Other common complications, recent developments, transplantation, and gene therapy are also reviewed.

UR - http://www.scopus.com/inward/record.url?scp=0029965836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029965836&partnerID=8YFLogxK

M3 - Article

C2 - 8732732

AN - SCOPUS:0029965836

VL - 164

SP - 321

EP - 334

JO - Western Journal of Medicine

JF - Western Journal of Medicine

SN - 0093-0415

IS - 4

ER -