Cyclosporine pharmacokinetics in cats following topical ocular administration

Clare R. Gregory, Sharon K. Hietala, Niels C Pedersen, Teri A. Gregory, Kim A. Floyd-Hawkins, John D. Patz

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Topical ocular administration of two forms of cyclosporine were studied in the cat. Both forms were able to produce measurable whole-blood levels capable of sup-pressing in vitro lymphocyte stimulation. The kinetics of cyclosporine following administration of either oral solution or cyclosporine in olive oil were variable, with peak concentrations ranging from 450 to 1033 ng/ml and 288 to 648 ng/ml, respectively. Absorption lag time ranged from 0 to 1.34 hr for oral solution, and 0.27 to 1.2 hr for cyclosporine in olive oil. The half- life of elimination ranged from 2.41 to 10.04 hr, and 3.09 to 15.75 hr, respectively. When compared with the commercially available oral solution, cyclosporine dissolved in olive oil was better tolerated during administration. Topical ocular administration of cyclosporine in cats offers a possible alternative method of treatment for individuals intolerant of oral administration. Topical ocular administration might also replace the need for intravenous administration of cyclosporine during per-ioperative periods or during periods of vomiting and nausea associated with rejection or other illnesses. Due to individual variation in absorption and elimination of topically applied cyclosporine, dosages in each cat must be determined by monitoring blood, plasma, or serum levels.

Original languageEnglish (US)
Pages (from-to)516-519
Number of pages4
JournalTransplantation
Volume47
Issue number3
StatePublished - 1989

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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    Gregory, C. R., Hietala, S. K., Pedersen, N. C., Gregory, T. A., Floyd-Hawkins, K. A., & Patz, J. D. (1989). Cyclosporine pharmacokinetics in cats following topical ocular administration. Transplantation, 47(3), 516-519.