Cyclosporine-induced immune suppression alters establishment of HTLV-1 infection in a rabbit model

Rashade A H Haynes, Evan Ware, Christopher Premanandan, Bevin Zimmerman, Lianbo Yu, Andrew J. Phipps, Michael Dale Lairmore

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) infection causes adult T-cell leukemia and several lymphocyte-mediated inflammatory diseases. Persistent HTLV-1 infection is determined by a balance between host immune responses and virus spread. Immunomodulatory therapy involving HTLV-1-infected patients occurs in a variety of clinical settings. Knowledge of how these treatments influence host-virus relationships is not understood. In this study, we examined the effects of cyclosporine A (CsA)-induced immune suppression during early infection of HTLV-1. Twenty-four New Zealand white rabbits were split into 4 groups. Three groups were treated with either 10 or 20 mg/kg CsA or saline before infection. The fourth group was treated with 20 mg/kg CsA 1 week after infection. Immune suppression, plasma CsA concentration, ex vivo lymphocyte HTLV-1 p19 production, anti-HTLV-1 serologic responses, and proviral load levels were measured during infection. Our data indicated that CsA treatment before HTLV-1 infection enhanced early viral expression compared with untreated HTLV-1-infected rabbits, and altered long-term viral expression parameters. However, CsA treatment 1 week after infection diminished HTLV-1 expression throughout the 10-week study course. Collectively, these data indicate immunologic control is a key determinant of early HTLV-1 spread and have important implications for therapeutic intervention during HTLV-1-associated diseases.

Original languageEnglish (US)
Pages (from-to)815-823
Number of pages9
JournalBlood
Volume115
Issue number4
DOIs
StatePublished - Jan 28 2010
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

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    Haynes, R. A. H., Ware, E., Premanandan, C., Zimmerman, B., Yu, L., Phipps, A. J., & Lairmore, M. D. (2010). Cyclosporine-induced immune suppression alters establishment of HTLV-1 infection in a rabbit model. Blood, 115(4), 815-823. https://doi.org/10.1182/blood-2009-07-230912