Cyclosporine and liver regeneration studied by in vivo31P nuclear magnetic resonance spectroscopy

Lorenzo Rossaro, Vincenzo Mazzaferro, Carlo L. Scotti-Foglieni, Kendrik A. Porter, Donald S. Williams, Elena Simplaceanu, Virgil Simplaceanu, Antonio Francavilla, Thomas E. Starzl, Chien Ho, Remo Naccarato, David H. Van Thiel

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The changes in fructose-1-phosphate (F-1-P), intracellular pH, and ATP content of the liver after a fructose challenge were investigated noninvasively in vivo using phosphorus-31 nuclear magnetic resonance spectroscopy of dog liver four days after a portacaval shunt (PCS) with or without portal venous infusion of cyclosporin (CsA). The F-1-P metabolism was slower in PCS dogs (N=2) as compared to either the normal (N=2) or PCS+CsA-treated dogs (N=3) (P<0.05). The intracellular pH temporarily decreased from 7.3±0.05 to 7.0±0.05 during the fructose challenge. The regenerative indexes were increased in the PCS+CsA group (P<0.01). These data obtained in vivo using31P-NMR spectroscopy in the liver following a portacaval shunt, suggest that : (1) the energy status of the liver and the metabolic response to fructose are reduced in PCS compared to normal animals and (2) CsA treatment enhances the regenerative response of the liver and prevents the reduction in hepatic function associated with portacaval shunting.

Original languageEnglish (US)
Pages (from-to)687-692
Number of pages6
JournalDigestive Diseases and Sciences
Issue number5
StatePublished - May 1991
Externally publishedYes


  • P nuclear magnetic resonance spectroscopy
  • cyclosporine
  • fructose
  • intracellular pH
  • liver regeneration
  • portacaval shunt

ASJC Scopus subject areas

  • Gastroenterology


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