Cyclosporin a does not increase the oxidative susceptibility of low density lipoprotein in vitro

Sridevi Devaraj, Dai J. Li, Miguel Vazquez, Ishwarlal Jialal

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Accelerated atherosclerosis is the leading cause of morbidity in renal transplant recipients. The pathogenic mechanisms responsible for the progression of atherosclerosis in renal transplant recipients have not been elucidated. Cyclosporin A (CsA) is an immunosuppressive agent used post- transplant and may contribute to increased oxidative susceptibility of low density lipoprotein (LDL). There is a paucity of data testing the effect of CsA on LDL oxidation. Hence, the aim of this study was to test the effect of in vitro enrichment of LDL with CsA on LDL oxidation. LDL oxidation in presence of different concentrations of CsA was tested using metal-dependent (copper), metal-independent (AAPH) and cell-mediated (macrophages) oxidation systems. In all 3 systems, CsA had no significant effect on LDL oxidation. Also, pre-incubation of LDL with CsA did not affect LDL oxidation and LDL alpha tocopherol levels. Thus, the results of our studies with CsA indicate that it is not a direct pro-oxidant.

Original languageEnglish (US)
Pages (from-to)1064-1068
Number of pages5
JournalFree Radical Biology and Medicine
Volume26
Issue number7-8
DOIs
StatePublished - Apr 1999
Externally publishedYes

Keywords

  • Atherosclerosis
  • Cyclosporin A
  • End stage renal disease
  • Free radicals
  • LDL oxidation
  • Renal transplant

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Cyclosporin a does not increase the oxidative susceptibility of low density lipoprotein in vitro'. Together they form a unique fingerprint.

Cite this