Cyclophosphamide: use in practice

M. Eric Gershwin, E. J. Goetzl, A. D. Steinberg

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Cyclophosphamide is a potent anti inflammatory and immunosuppressive cytostatic and cytotoxic drug used for such diverse medical problems as neoplasia, tissue transplantation, and inflammatory disease of uncertain cause. The drug is inactive until converted to active metabolites in the liver. The serum half life in humans is about 6.5 hr, and both metabolism and toxicity vary with body surface area. Cyclophosphamide treatment kills both rapidly proliferating cells and resting lymphoid cells. This leads to a reduction of circulating small lymphocytes as well as impaired humoral and cellular immune responses. Infectious complications may result. Toxicity is also particularly evident in the urologic system where sterile hemorrhagic cystitis is a common problem. Other reactions include infertility in both sexes, pneumonitis after treatment, and inappropriate secretion of antidiuretic hormone. Guidelines should be carefully followed in prescribing immunosuppressive drugs.

Original languageEnglish (US)
Pages (from-to)531-540
Number of pages10
JournalAnnals of Internal Medicine
Volume80
Issue number4
StatePublished - 1974
Externally publishedYes

Fingerprint

Immunosuppressive Agents
Cyclophosphamide
Lymphocytes
Inappropriate ADH Syndrome
Drug Prescriptions
Tissue Transplantation
Cystitis
Body Surface Area
Cytostatic Agents
Humoral Immunity
Cellular Immunity
Infertility
Half-Life
Pneumonia
Anti-Inflammatory Agents
Guidelines
Liver
Therapeutics
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gershwin, M. E., Goetzl, E. J., & Steinberg, A. D. (1974). Cyclophosphamide: use in practice. Annals of Internal Medicine, 80(4), 531-540.

Cyclophosphamide : use in practice. / Gershwin, M. Eric; Goetzl, E. J.; Steinberg, A. D.

In: Annals of Internal Medicine, Vol. 80, No. 4, 1974, p. 531-540.

Research output: Contribution to journalArticle

Gershwin, ME, Goetzl, EJ & Steinberg, AD 1974, 'Cyclophosphamide: use in practice', Annals of Internal Medicine, vol. 80, no. 4, pp. 531-540.
Gershwin ME, Goetzl EJ, Steinberg AD. Cyclophosphamide: use in practice. Annals of Internal Medicine. 1974;80(4):531-540.
Gershwin, M. Eric ; Goetzl, E. J. ; Steinberg, A. D. / Cyclophosphamide : use in practice. In: Annals of Internal Medicine. 1974 ; Vol. 80, No. 4. pp. 531-540.
@article{2a8db47035344a078ac7f3a811b305b8,
title = "Cyclophosphamide: use in practice",
abstract = "Cyclophosphamide is a potent anti inflammatory and immunosuppressive cytostatic and cytotoxic drug used for such diverse medical problems as neoplasia, tissue transplantation, and inflammatory disease of uncertain cause. The drug is inactive until converted to active metabolites in the liver. The serum half life in humans is about 6.5 hr, and both metabolism and toxicity vary with body surface area. Cyclophosphamide treatment kills both rapidly proliferating cells and resting lymphoid cells. This leads to a reduction of circulating small lymphocytes as well as impaired humoral and cellular immune responses. Infectious complications may result. Toxicity is also particularly evident in the urologic system where sterile hemorrhagic cystitis is a common problem. Other reactions include infertility in both sexes, pneumonitis after treatment, and inappropriate secretion of antidiuretic hormone. Guidelines should be carefully followed in prescribing immunosuppressive drugs.",
author = "Gershwin, {M. Eric} and Goetzl, {E. J.} and Steinberg, {A. D.}",
year = "1974",
language = "English (US)",
volume = "80",
pages = "531--540",
journal = "Annals of Internal Medicine",
issn = "0003-4819",
publisher = "American College of Physicians",
number = "4",

}

TY - JOUR

T1 - Cyclophosphamide

T2 - use in practice

AU - Gershwin, M. Eric

AU - Goetzl, E. J.

AU - Steinberg, A. D.

PY - 1974

Y1 - 1974

N2 - Cyclophosphamide is a potent anti inflammatory and immunosuppressive cytostatic and cytotoxic drug used for such diverse medical problems as neoplasia, tissue transplantation, and inflammatory disease of uncertain cause. The drug is inactive until converted to active metabolites in the liver. The serum half life in humans is about 6.5 hr, and both metabolism and toxicity vary with body surface area. Cyclophosphamide treatment kills both rapidly proliferating cells and resting lymphoid cells. This leads to a reduction of circulating small lymphocytes as well as impaired humoral and cellular immune responses. Infectious complications may result. Toxicity is also particularly evident in the urologic system where sterile hemorrhagic cystitis is a common problem. Other reactions include infertility in both sexes, pneumonitis after treatment, and inappropriate secretion of antidiuretic hormone. Guidelines should be carefully followed in prescribing immunosuppressive drugs.

AB - Cyclophosphamide is a potent anti inflammatory and immunosuppressive cytostatic and cytotoxic drug used for such diverse medical problems as neoplasia, tissue transplantation, and inflammatory disease of uncertain cause. The drug is inactive until converted to active metabolites in the liver. The serum half life in humans is about 6.5 hr, and both metabolism and toxicity vary with body surface area. Cyclophosphamide treatment kills both rapidly proliferating cells and resting lymphoid cells. This leads to a reduction of circulating small lymphocytes as well as impaired humoral and cellular immune responses. Infectious complications may result. Toxicity is also particularly evident in the urologic system where sterile hemorrhagic cystitis is a common problem. Other reactions include infertility in both sexes, pneumonitis after treatment, and inappropriate secretion of antidiuretic hormone. Guidelines should be carefully followed in prescribing immunosuppressive drugs.

UR - http://www.scopus.com/inward/record.url?scp=0016379441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016379441&partnerID=8YFLogxK

M3 - Article

C2 - 4621265

AN - SCOPUS:0016379441

VL - 80

SP - 531

EP - 540

JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

SN - 0003-4819

IS - 4

ER -