Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis

Juan Anguita, Swapna Samanta, Shobana K. Ananthanarayanan, Beatriz Revilla, Gregory P. Geba, Stephen W Barthold, Erol Fikrig

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Cyclooxygenase (Cox) is a key enzyme in the biosynthetic metabolism of prostaglandins. The inducible isoform of Cox-2 has been implicated in inflammation and its specific inhibition can be used to treat noninfectious inflammatory diseases, such as rheumatoid arthritis. Borrelia burgdorferi, the agent of Lyme disease, can induce joint inflammation. Here we show that B. burgdorferi induced the upregulation of cox-2 gene expression in murine joints at the onset of arthritis in infected mice. The level of mRNA expression correlated with the degree of inflammation. The specific inhibition of Cox-2 diminished the degree of joint inflammation, without affecting B. burgdorferi-specific antibody or cytokine responses. Cox-2 activity is therefore associated with the genesis of infectious arthritis caused by B. burgdorferi.

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalFEMS Immunology and Medical Microbiology
Volume34
Issue number3
DOIs
StatePublished - Nov 15 2002

Keywords

  • Borrelia burgdorferi
  • Cyclooxygenase-2
  • Inflammation
  • Lyme arthritis

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis'. Together they form a unique fingerprint.

  • Cite this

    Anguita, J., Samanta, S., Ananthanarayanan, S. K., Revilla, B., Geba, G. P., Barthold, S. W., & Fikrig, E. (2002). Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis. FEMS Immunology and Medical Microbiology, 34(3), 187-191. https://doi.org/10.1016/S0928-8244(02)00376-0