Cyclodextrin complexed [60]fullerene derivatives with high levels of photodynamic activity by long wavelength excitation

Atsushi Ikeda, Tatsuya Iizuka, Naotake Maekubo, Ryota Aono, Jun Ichi Kikuchi, Motofusa Akiyama, Toshifumi Konishi, Takuya Ogawa, Norihiro Ishida-Kitagawa, Hisashi Tatebe, Kazuhiro Shiozaki

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

We have evaluated the photodynamic activities of C60 derivative·γ-cyclodextrin (γ-CDx) complexes and demonstrated that they were significantly higher than those of the pristine C60 and C70·γ-CDx complexes under photoirradiation at long wavelengths (610-720 nm), which represent the optimal wavelengths for photodynamic therapy (PDT). In particular, the cationic C60 derivative·γ-CDx complex had the highest photodynamic ability because the complex possessed the ability to generate high levels of 1O2 and provided a higher level of intracellular uptake. The photodynamic activity of this complex was greater than that of photofrin, which is the most widely used of the known clinical photosensitizers. These findings therefore provide a significant level of information toward the optimization of molecular design strategies for the synthesis of fullerene derivatives for PDT.

Original languageEnglish (US)
Pages (from-to)752-756
Number of pages5
JournalACS Medicinal Chemistry Letters
Volume4
Issue number8
DOIs
StatePublished - Aug 8 2013
Externally publishedYes

Keywords

  • cyclodextrin
  • Fullerenes
  • photodynamic therapy
  • photosensitizers

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Biochemistry

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    Ikeda, A., Iizuka, T., Maekubo, N., Aono, R., Kikuchi, J. I., Akiyama, M., Konishi, T., Ogawa, T., Ishida-Kitagawa, N., Tatebe, H., & Shiozaki, K. (2013). Cyclodextrin complexed [60]fullerene derivatives with high levels of photodynamic activity by long wavelength excitation. ACS Medicinal Chemistry Letters, 4(8), 752-756. https://doi.org/10.1021/ml4001535