Cyclobutene formation accompanying an intramolecular Lewis acid-promoted spirocyclization of a propargylic silane

John D. Spence, Lee E. Lowrie, Michael H. Nantz

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

An intramolecular Lewis acid-promoted conjugate addition of a propargylic silane to a functionalized cyclohex-2-en-1-one resulted in part in the remarkable formation of a highly fused cyclobutene. The reaction was found to be dependent on the stoichiometry and selection of Lewis acid.

Original languageEnglish (US)
Pages (from-to)5499-5502
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number31
DOIs
StatePublished - Jul 31 1995

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Silanes
Lewis Acids
Stoichiometry

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Cyclobutene formation accompanying an intramolecular Lewis acid-promoted spirocyclization of a propargylic silane. / Spence, John D.; Lowrie, Lee E.; Nantz, Michael H.

In: Tetrahedron Letters, Vol. 36, No. 31, 31.07.1995, p. 5499-5502.

Research output: Contribution to journal › Article

Spence, JD, Lowrie, LE & Nantz, MH 1995, 'Cyclobutene formation accompanying an intramolecular Lewis acid-promoted spirocyclization of a propargylic silane', Tetrahedron Letters, vol. 36, no. 31, pp. 5499-5502. https://doi.org/10.1016/0040-4039(95)01115-X
Spence JD, Lowrie LE, Nantz MH. Cyclobutene formation accompanying an intramolecular Lewis acid-promoted spirocyclization of a propargylic silane. Tetrahedron Letters. 1995 Jul 31;36(31):5499-5502. https://doi.org/10.1016/0040-4039(95)01115-X
Spence, John D. ; Lowrie, Lee E. ; Nantz, Michael H. / Cyclobutene formation accompanying an intramolecular Lewis acid-promoted spirocyclization of a propargylic silane. In: Tetrahedron Letters. 1995 ; Vol. 36, No. 31. pp. 5499-5502.
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