Cyclobutene formation accompanying an intramolecular Lewis acid-promoted spirocyclization of a propargylic silane

John D. Spence; Lee E. Lowrie; Michael H. Nantz

doi:10.1016/0040-4039(95)01115-X

Cyclobutene formation accompanying an intramolecular Lewis acid-promoted spirocyclization of a propargylic silane

John D. Spence, Lee E. Lowrie, Michael H. Nantz

Chemistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

An intramolecular Lewis acid-promoted conjugate addition of a propargylic silane to a functionalized cyclohex-2-en-1-one resulted in part in the remarkable formation of a highly fused cyclobutene. The reaction was found to be dependent on the stoichiometry and selection of Lewis acid.

Original language	English (US)
Pages (from-to)	5499-5502
Number of pages	4
Journal	Tetrahedron Letters
Volume	36
Issue number	31
DOIs	https://doi.org/10.1016/0040-4039(95)01115-X
State	Published - Jul 31 1995

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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title = "Cyclobutene formation accompanying an intramolecular Lewis acid-promoted spirocyclization of a propargylic silane",

abstract = "An intramolecular Lewis acid-promoted conjugate addition of a propargylic silane to a functionalized cyclohex-2-en-1-one resulted in part in the remarkable formation of a highly fused cyclobutene. The reaction was found to be dependent on the stoichiometry and selection of Lewis acid.",

author = "Spence, {John D.} and Lowrie, {Lee E.} and Nantz, {Michael H.}",

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AU - Lowrie, Lee E.

AU - Nantz, Michael H.

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AB - An intramolecular Lewis acid-promoted conjugate addition of a propargylic silane to a functionalized cyclohex-2-en-1-one resulted in part in the remarkable formation of a highly fused cyclobutene. The reaction was found to be dependent on the stoichiometry and selection of Lewis acid.

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