Cyclobutene formation accompanying an intramolecular Lewis acid-promoted spirocyclization of a propargylic silane

John D. Spence, Lee E. Lowrie, Michael H. Nantz

Research output: Contribution to journalArticle

10 Scopus citations


An intramolecular Lewis acid-promoted conjugate addition of a propargylic silane to a functionalized cyclohex-2-en-1-one resulted in part in the remarkable formation of a highly fused cyclobutene. The reaction was found to be dependent on the stoichiometry and selection of Lewis acid.

Original languageEnglish (US)
Pages (from-to)5499-5502
Number of pages4
JournalTetrahedron Letters
Issue number31
StatePublished - Jul 31 1995


ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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