Cyclin B1/Cdk1 coordinates mitochondrial respiration for Cell-Cycle G2/M progression

Zhaoqing Wang, Ming Fan, Demet Candas, Tie Qiao Zhang, Lili Qin, Angela Eldridge, Sebastian Wachsmann-Hogiu, Kazi M. Ahmed, Brett A. Chromy, Danupon Nantajit, Nadire Duru, Fuchu He, Min Chen, Toren Finkel, Lee S. Weinstein, Jian-Jian Li

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

A substantial amount of mitochondrial energy is required for cell-cycle progression. The mechanisms underlying the coordination of the mitochondrial respiration with cell-cycle progression, especially the G2/M transition, remain to be elucidated. Here, we show that a fraction of cyclin B1/Cdk1 proteins localizes to the matrix of mitochondria and phosphorylates a cluster of mitochondrial proteins, including the complex I (CI) subunits in the respiratory chain. Cyclin B1/Cdk1-mediated CI phosphorylation enhances CI activity, whereas deficiency of such phosphorylation in each of the relevant CI subunits results in impairment of CI function. Mitochondria-targeted cyclin B1/Cdk1 increases mitochondrial respiration with enhanced oxygen consumption and ATP generation, which provides cells with efficient bioenergy for G2/M transition and shortens overall cell-cycle time. Thus, cyclin B1/Cdk1-mediated phosphorylation of mitochondrial substrates allows cells to sense and respond to increased energy demand for G2/M transition and, subsequently, to upregulate mitochondrial respiration for successful cell-cycle progression.

Original languageEnglish (US)
Pages (from-to)217-232
Number of pages16
JournalDevelopmental Cell
Volume29
Issue number2
DOIs
StatePublished - Apr 28 2014

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Cyclin B1
Phosphorylation
Cell Cycle
Respiration
Cells
Mitochondria
Mitochondrial Proteins
Electron Transport
Oxygen Consumption
Up-Regulation
Adenosine Triphosphate
Oxygen
Substrates
Proteins

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Cyclin B1/Cdk1 coordinates mitochondrial respiration for Cell-Cycle G2/M progression. / Wang, Zhaoqing; Fan, Ming; Candas, Demet; Zhang, Tie Qiao; Qin, Lili; Eldridge, Angela; Wachsmann-Hogiu, Sebastian; Ahmed, Kazi M.; Chromy, Brett A.; Nantajit, Danupon; Duru, Nadire; He, Fuchu; Chen, Min; Finkel, Toren; Weinstein, Lee S.; Li, Jian-Jian.

In: Developmental Cell, Vol. 29, No. 2, 28.04.2014, p. 217-232.

Research output: Contribution to journalArticle

Wang, Z, Fan, M, Candas, D, Zhang, TQ, Qin, L, Eldridge, A, Wachsmann-Hogiu, S, Ahmed, KM, Chromy, BA, Nantajit, D, Duru, N, He, F, Chen, M, Finkel, T, Weinstein, LS & Li, J-J 2014, 'Cyclin B1/Cdk1 coordinates mitochondrial respiration for Cell-Cycle G2/M progression', Developmental Cell, vol. 29, no. 2, pp. 217-232. https://doi.org/10.1016/j.devcel.2014.03.012
Wang, Zhaoqing ; Fan, Ming ; Candas, Demet ; Zhang, Tie Qiao ; Qin, Lili ; Eldridge, Angela ; Wachsmann-Hogiu, Sebastian ; Ahmed, Kazi M. ; Chromy, Brett A. ; Nantajit, Danupon ; Duru, Nadire ; He, Fuchu ; Chen, Min ; Finkel, Toren ; Weinstein, Lee S. ; Li, Jian-Jian. / Cyclin B1/Cdk1 coordinates mitochondrial respiration for Cell-Cycle G2/M progression. In: Developmental Cell. 2014 ; Vol. 29, No. 2. pp. 217-232.
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