Abstract
An acylketene mediated cyclization protocol delivers a series of cyclic oligolides, the largest characterized cyclic oligolide having a 77-membered ring. 6-(ω-Hydroxyalkyl)dioxinone analogs were prepared and cyclizations were conducted under a variety of conditions in refluxing toluene. 1H-NMR, 13C-NMR, and several different mass spectrometric techniques were employed to verify the cyclic nature of these oligolides.
Original language | English (US) |
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Pages (from-to) | 7683-7686 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 37 |
Issue number | 43 |
DOIs | |
State | Published - Oct 21 1996 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery