Cyclic oligolides via acylketene mediated lactonization: Synthesis and characterization

Shawn W E Eisenberg, Chixu Chen, Jiangyue Wu, Carlito B Lebrilla, Mark J. Kurth

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

An acylketene mediated cyclization protocol delivers a series of cyclic oligolides, the largest characterized cyclic oligolide having a 77-membered ring. 6-(ω-Hydroxyalkyl)dioxinone analogs were prepared and cyclizations were conducted under a variety of conditions in refluxing toluene. 1H-NMR, 13C-NMR, and several different mass spectrometric techniques were employed to verify the cyclic nature of these oligolides.

Original languageEnglish (US)
Pages (from-to)7683-7686
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number43
DOIs
StatePublished - Oct 21 1996

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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