Abstract
An acylketene mediated cyclization protocol delivers a series of cyclic oligolides, the largest characterized cyclic oligolide having a 77-membered ring. 6-(ω-Hydroxyalkyl)dioxinone analogs were prepared and cyclizations were conducted under a variety of conditions in refluxing toluene. 1H-NMR, 13C-NMR, and several different mass spectrometric techniques were employed to verify the cyclic nature of these oligolides.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7683-7686 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 37 |
| Issue number | 43 |
| DOIs | |
| State | Published - Oct 21 1996 |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Cyclic oligolides via acylketene mediated lactonization : Synthesis and characterization. / Eisenberg, Shawn W E; Chen, Chixu; Wu, Jiangyue; Lebrilla, Carlito B; Kurth, Mark J.
In: Tetrahedron Letters, Vol. 37, No. 43, 21.10.1996, p. 7683-7686.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cyclic oligolides via acylketene mediated lactonization
T2 - Synthesis and characterization
AU - Eisenberg, Shawn W E
AU - Chen, Chixu
AU - Wu, Jiangyue
AU - Lebrilla, Carlito B
AU - Kurth, Mark J.
PY - 1996/10/21
Y1 - 1996/10/21
N2 - An acylketene mediated cyclization protocol delivers a series of cyclic oligolides, the largest characterized cyclic oligolide having a 77-membered ring. 6-(ω-Hydroxyalkyl)dioxinone analogs were prepared and cyclizations were conducted under a variety of conditions in refluxing toluene. 1H-NMR, 13C-NMR, and several different mass spectrometric techniques were employed to verify the cyclic nature of these oligolides.
AB - An acylketene mediated cyclization protocol delivers a series of cyclic oligolides, the largest characterized cyclic oligolide having a 77-membered ring. 6-(ω-Hydroxyalkyl)dioxinone analogs were prepared and cyclizations were conducted under a variety of conditions in refluxing toluene. 1H-NMR, 13C-NMR, and several different mass spectrometric techniques were employed to verify the cyclic nature of these oligolides.
UR - http://www.scopus.com/inward/record.url?scp=0030597171&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030597171&partnerID=8YFLogxK
U2 - 10.1016/0040-4039(96)01757-1
DO - 10.1016/0040-4039(96)01757-1
M3 - Article
AN - SCOPUS:0030597171
VL - 37
SP - 7683
EP - 7686
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 43
ER -