Curative surgery is not an option for many patients with clinical stage I non-small-cell lung carcinoma (NSCLC) because of associated comorbidities. Stereotactic radiosurgery with the CyberKnife® (Accuray Incorporated, Sunnyvale, CA) tumor tracking system may be an option for many of these medically inoperable patients. Here we provide a concise overview of the standard treatment options for stage I lung cancer and a practical summary of the Georgetown University Hospital stereotactic radiosurgery treatment protocol. We review preliminary outcomes for single small peripheral lung tumors uniformly treated with the CyberKnife using the Synchrony® (Accuray Incorporated, Sunnyvale, CA) motion tracking module.
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