TY - JOUR
T1 - CXCR5+ CD4+ T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis
AU - Wang, Lifeng
AU - Sun, Ying
AU - Zhang, Zheng
AU - Jia, Yiqiong
AU - Zou, Zhengsheng
AU - Ding, Jinbiao
AU - Li, Yuanyuan
AU - Xu, Xiangsheng
AU - Jin, Lei
AU - Yang, Tao
AU - Li, Zhiwei
AU - Sun, Yanling
AU - Zhang, Ji yuan
AU - Lv, Sa
AU - Chen, Liming
AU - Li, Baosen
AU - Gershwin, M. Eric
AU - Wang, Fu Sheng
PY - 2015/2/1
Y1 - 2015/2/1
N2 - There is increasing interest in the role of T follicular helper (Tfh) cells in autoimmunity from the perspective of both their role in breach of tolerance and their effects on the natural history of disease progression. Indeed, the critical role of Tfh cells in autoimmunity is further highlighted based on their location in the germinal center (GC), a pathogenic hot spot for development of autoreactivity. To address the role of Tfh cells in primary biliary cirrhosis (PBC), we comprehensively evaluated the immunobiology of CXCR5+CD4+ Tfh cells in 69 patients with PBC, including a nested subgroup of 16 autoimmune hepatitis (AIH) and 20 healthy controls (HC), followed for 1 year. We report herein several key observations. First, there was an increased frequency of circulating Tfh cells in patients with PBC compared to AIH (P<0.05) and HC (P<0.01). Second, the function of circulating Tfh cells from PBC patients, including interleukin (IL)-21 production (P<0.05), the ability to promote B-cell maturation, and autoantibody production, were greater than HC. Third, the frequency of these cells was significantly decreased in ursodeoxycholic acid (UDCA) responders compared to UDCA-treated nonresponders, in both cross-sectional (P=0.023) and longitudinal studies (P=0.036), respectively. Indeed, similar increases of Tfh cells were noted in liver and spleen. Conclusion: These results significantly extend our understanding of lymphoid subpopulations in PBC and their relative role in disease expression. Our data also provide a novel biomarker for evaluation of the effectiveness of new therapeutic approaches.
AB - There is increasing interest in the role of T follicular helper (Tfh) cells in autoimmunity from the perspective of both their role in breach of tolerance and their effects on the natural history of disease progression. Indeed, the critical role of Tfh cells in autoimmunity is further highlighted based on their location in the germinal center (GC), a pathogenic hot spot for development of autoreactivity. To address the role of Tfh cells in primary biliary cirrhosis (PBC), we comprehensively evaluated the immunobiology of CXCR5+CD4+ Tfh cells in 69 patients with PBC, including a nested subgroup of 16 autoimmune hepatitis (AIH) and 20 healthy controls (HC), followed for 1 year. We report herein several key observations. First, there was an increased frequency of circulating Tfh cells in patients with PBC compared to AIH (P<0.05) and HC (P<0.01). Second, the function of circulating Tfh cells from PBC patients, including interleukin (IL)-21 production (P<0.05), the ability to promote B-cell maturation, and autoantibody production, were greater than HC. Third, the frequency of these cells was significantly decreased in ursodeoxycholic acid (UDCA) responders compared to UDCA-treated nonresponders, in both cross-sectional (P=0.023) and longitudinal studies (P=0.036), respectively. Indeed, similar increases of Tfh cells were noted in liver and spleen. Conclusion: These results significantly extend our understanding of lymphoid subpopulations in PBC and their relative role in disease expression. Our data also provide a novel biomarker for evaluation of the effectiveness of new therapeutic approaches.
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U2 - 10.1002/hep.27306
DO - 10.1002/hep.27306
M3 - Article
C2 - 25042122
AN - SCOPUS:84921503782
VL - 61
SP - 627
EP - 638
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 2
ER -