Cutting edge

T cell-mediated pathology in murine Lyme borreliosis

Maureen D. McKisic, William L. Redmond, Stephen W Barthold

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Even in the absence of an appropriate model or direct evidence, T cells have been hypothesized to exacerbate the manifestations of Lyme disease. To define definitely the role of T cells in Lyme disease, the course of disease in immunocompetent and B cell-deficient mice was compared. By 8 wk postinoculation, immunocompetent mice resolved both carditis and arthritis, whereas foci of myocarditis and severe destructive arthritis characterized disease of B cell-deficient mice. Cell transfer experiments using infected B6-Rag1 knock out mice demonstrated that: 1) innate immunity mediated the initial sequelae of infection, 2) transferring both naive T cells and B cells induced resolution of carditis and arthritis, 3) infected mice reconstituted with T cells developed myocarditis and severe destructive arthritis, and 4) CD4+ T cells were responsible for the observed immune-mediated pathology. These data demonstrate directly the deleterious effect of T cells in Lyme disease.

Original languageEnglish (US)
Pages (from-to)6096-6099
Number of pages4
JournalJournal of Immunology
Volume164
Issue number12
StatePublished - Jun 15 2000

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Lyme Disease
Myocarditis
Pathology
T-Lymphocytes
Arthritis
B-Lymphocytes
Innate Immunity
Knockout Mice
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Cutting edge : T cell-mediated pathology in murine Lyme borreliosis. / McKisic, Maureen D.; Redmond, William L.; Barthold, Stephen W.

In: Journal of Immunology, Vol. 164, No. 12, 15.06.2000, p. 6096-6099.

Research output: Contribution to journalArticle

McKisic, MD, Redmond, WL & Barthold, SW 2000, 'Cutting edge: T cell-mediated pathology in murine Lyme borreliosis', Journal of Immunology, vol. 164, no. 12, pp. 6096-6099.
McKisic, Maureen D. ; Redmond, William L. ; Barthold, Stephen W. / Cutting edge : T cell-mediated pathology in murine Lyme borreliosis. In: Journal of Immunology. 2000 ; Vol. 164, No. 12. pp. 6096-6099.
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