Cutting-Edge issues in primary biliary cirrhosis

Marco Folci, Francesca Meda, M. Eric Gershwin, Carlo Selmi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Several crucial issues remain open in our understanding of primary biliary cirrhosis (PBC), an autoimmune liver disease targeting the small- and medium-sized intra-hepatic bile ducts. These issues include the high tissue specificity ofthe autoimmune injury despite the nontraditional autoantigens found in all mitochondria recognized by PBC-associated autoantibodies, the causes of the commonly observed pruritus, and the disease etiology per se. In all these fields, there has been recent interest secondary to the use of large-scale efforts (such as genome-wide association studies) that were previously considered poorly feasible in a rare disease such as PBC as well as other intuitions. Accordingly, there are now fascinating theories to explain the onset and severity of pruritus due to elevated autotaxin levels, the peculiar apoptotic features of bile duct cells to explain the tissue specificity, and genomic and epigenetic associations contributing to disease susceptibility. We have arbitrarily chosen these four aspects as the most promising in the PBC recent literature and will provide herein a discussion of the recent data and their potential implications.

Original languageEnglish (US)
Pages (from-to)342-354
Number of pages13
JournalClinical Reviews in Allergy and Immunology
Volume42
Issue number3
DOIs
StatePublished - Jun 2012

Fingerprint

Biliary Liver Cirrhosis
Organ Specificity
Pruritus
Bile Ducts
Common Hepatic Duct
Intuition
Genome-Wide Association Study
Disease Susceptibility
Autoantigens
Rare Diseases
Epigenomics
Autoantibodies
Autoimmune Diseases
Liver Diseases
Mitochondria
Wounds and Injuries

Keywords

  • Apoptosis
  • Autoimmune cholangitis
  • Autotaxin
  • Epigenetics
  • GWAS

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Cutting-Edge issues in primary biliary cirrhosis. / Folci, Marco; Meda, Francesca; Gershwin, M. Eric; Selmi, Carlo.

In: Clinical Reviews in Allergy and Immunology, Vol. 42, No. 3, 06.2012, p. 342-354.

Research output: Contribution to journalArticle

Folci, Marco ; Meda, Francesca ; Gershwin, M. Eric ; Selmi, Carlo. / Cutting-Edge issues in primary biliary cirrhosis. In: Clinical Reviews in Allergy and Immunology. 2012 ; Vol. 42, No. 3. pp. 342-354.
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