Abstract
There have been numerous methods and ways to classify autoimmune diseases. By far, the most traditional has been to separate immune-mediated pathology into organ-specific and organ-non-specific diseases. The classic systemic autoimmune diseases are, of course, rheumatoid arthritis and systemic lupus. The classic organ-specific autoimmune diseases have been autoimmune thyroiditis and autoimmune gastritis. However, as our understanding of the loss of tolerance has expanded, so has the long list of autoimmune diseases. In many cases, the distinction between organ-specific and organ-non-specific or systemic autoimmunity becomes a blur. In this issue, we discuss recent concepts in autoimmune pancreatitis, primary sclerosing cholangitis, Goodpasture's syndrome, myofasciitis, type I diabetes, polymyositis, autoimmune thyroid disease, IgA nephropathy, autoimmune uveitis, and ANCA-associated vasculitis. Common themes on both etiology and effector mechanisms are described throughout these papers with an attempt to provide a cutting-edge overview.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 123-125 |
| Number of pages | 3 |
| Journal | Clinical Reviews in Allergy and Immunology |
| Volume | 41 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 2011 |
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Keywords
- Autoimmunity
- Cytotoxic T cells
- Organ-specific pathology
ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Cutting-edge issues in organ-specific autoimmunity. / Gershwin, M. Eric; Shoenfeld, Yehuda.
In: Clinical Reviews in Allergy and Immunology, Vol. 41, No. 2, 10.2011, p. 123-125.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cutting-edge issues in organ-specific autoimmunity
AU - Gershwin, M. Eric
AU - Shoenfeld, Yehuda
PY - 2011/10
Y1 - 2011/10
N2 - There have been numerous methods and ways to classify autoimmune diseases. By far, the most traditional has been to separate immune-mediated pathology into organ-specific and organ-non-specific diseases. The classic systemic autoimmune diseases are, of course, rheumatoid arthritis and systemic lupus. The classic organ-specific autoimmune diseases have been autoimmune thyroiditis and autoimmune gastritis. However, as our understanding of the loss of tolerance has expanded, so has the long list of autoimmune diseases. In many cases, the distinction between organ-specific and organ-non-specific or systemic autoimmunity becomes a blur. In this issue, we discuss recent concepts in autoimmune pancreatitis, primary sclerosing cholangitis, Goodpasture's syndrome, myofasciitis, type I diabetes, polymyositis, autoimmune thyroid disease, IgA nephropathy, autoimmune uveitis, and ANCA-associated vasculitis. Common themes on both etiology and effector mechanisms are described throughout these papers with an attempt to provide a cutting-edge overview.
AB - There have been numerous methods and ways to classify autoimmune diseases. By far, the most traditional has been to separate immune-mediated pathology into organ-specific and organ-non-specific diseases. The classic systemic autoimmune diseases are, of course, rheumatoid arthritis and systemic lupus. The classic organ-specific autoimmune diseases have been autoimmune thyroiditis and autoimmune gastritis. However, as our understanding of the loss of tolerance has expanded, so has the long list of autoimmune diseases. In many cases, the distinction between organ-specific and organ-non-specific or systemic autoimmunity becomes a blur. In this issue, we discuss recent concepts in autoimmune pancreatitis, primary sclerosing cholangitis, Goodpasture's syndrome, myofasciitis, type I diabetes, polymyositis, autoimmune thyroid disease, IgA nephropathy, autoimmune uveitis, and ANCA-associated vasculitis. Common themes on both etiology and effector mechanisms are described throughout these papers with an attempt to provide a cutting-edge overview.
KW - Autoimmunity
KW - Cytotoxic T cells
KW - Organ-specific pathology
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U2 - 10.1007/s12016-011-8283-x
DO - 10.1007/s12016-011-8283-x
M3 - Article
C2 - 21887609
AN - SCOPUS:80054963093
VL - 41
SP - 123
EP - 125
JO - Clinical Reviews in Allergy and Immunology
JF - Clinical Reviews in Allergy and Immunology
SN - 1080-0549
IS - 2
ER -