Cutting edge: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi

H. Kumar, A. Belperron, Stephen W Barthold, L. K. Bockenstedt

Research output: Contribution to journalArticle

146 Scopus citations

Abstract

CD1 molecules can present microbial lipid Ag to T cells, suggesting that they participate in host defense against pathogens. In this study, we examined the role of CD1d in resistance to infection with the Lyme disease spirochete, Borrelia burgdorferi (Bb), an organism with proinflammatory lipid Ag. Bb infection of CD1d-deficient (CD1d(-/-)) mouse strains normally resistant to this pathogen resulted in arthritis. Pathology correlated with an increased prevalence of spirochete DNA in tissues and enhanced production of Bb-specific IgG, including IgG to Ag rapidly down-modulated on spirochetes in vivo. CD1d(-/-) mice exhibited high-titer Bb-specific IgG2a, an iso-type commonly induced in disease-susceptible mice but not in the disease-resistant control mice in this study. These results show that CD1d deficiency impairs host resistance to a spirochete pathogen, and are the first example of a mutation that imparts Bb-resistant mice with the Ab and disease profile of a susceptible mouse strain.

Original languageEnglish (US)
Pages (from-to)4797-4801
Number of pages5
JournalJournal of Immunology
Volume165
Issue number9
StatePublished - Nov 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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