Abstract
CD1 molecules can present microbial lipid Ag to T cells, suggesting that they participate in host defense against pathogens. In this study, we examined the role of CD1d in resistance to infection with the Lyme disease spirochete, Borrelia burgdorferi (Bb), an organism with proinflammatory lipid Ag. Bb infection of CD1d-deficient (CD1d(-/-)) mouse strains normally resistant to this pathogen resulted in arthritis. Pathology correlated with an increased prevalence of spirochete DNA in tissues and enhanced production of Bb-specific IgG, including IgG to Ag rapidly down-modulated on spirochetes in vivo. CD1d(-/-) mice exhibited high-titer Bb-specific IgG2a, an iso-type commonly induced in disease-susceptible mice but not in the disease-resistant control mice in this study. These results show that CD1d deficiency impairs host resistance to a spirochete pathogen, and are the first example of a mutation that imparts Bb-resistant mice with the Ab and disease profile of a susceptible mouse strain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4797-4801 |
| Number of pages | 5 |
| Journal | Journal of Immunology |
| Volume | 165 |
| Issue number | 9 |
| State | Published - Nov 1 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Cutting edge : CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi. / Kumar, H.; Belperron, A.; Barthold, Stephen W; Bockenstedt, L. K.
In: Journal of Immunology, Vol. 165, No. 9, 01.11.2000, p. 4797-4801.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cutting edge
T2 - CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi
AU - Kumar, H.
AU - Belperron, A.
AU - Barthold, Stephen W
AU - Bockenstedt, L. K.
PY - 2000/11/1
Y1 - 2000/11/1
N2 - CD1 molecules can present microbial lipid Ag to T cells, suggesting that they participate in host defense against pathogens. In this study, we examined the role of CD1d in resistance to infection with the Lyme disease spirochete, Borrelia burgdorferi (Bb), an organism with proinflammatory lipid Ag. Bb infection of CD1d-deficient (CD1d(-/-)) mouse strains normally resistant to this pathogen resulted in arthritis. Pathology correlated with an increased prevalence of spirochete DNA in tissues and enhanced production of Bb-specific IgG, including IgG to Ag rapidly down-modulated on spirochetes in vivo. CD1d(-/-) mice exhibited high-titer Bb-specific IgG2a, an iso-type commonly induced in disease-susceptible mice but not in the disease-resistant control mice in this study. These results show that CD1d deficiency impairs host resistance to a spirochete pathogen, and are the first example of a mutation that imparts Bb-resistant mice with the Ab and disease profile of a susceptible mouse strain.
AB - CD1 molecules can present microbial lipid Ag to T cells, suggesting that they participate in host defense against pathogens. In this study, we examined the role of CD1d in resistance to infection with the Lyme disease spirochete, Borrelia burgdorferi (Bb), an organism with proinflammatory lipid Ag. Bb infection of CD1d-deficient (CD1d(-/-)) mouse strains normally resistant to this pathogen resulted in arthritis. Pathology correlated with an increased prevalence of spirochete DNA in tissues and enhanced production of Bb-specific IgG, including IgG to Ag rapidly down-modulated on spirochetes in vivo. CD1d(-/-) mice exhibited high-titer Bb-specific IgG2a, an iso-type commonly induced in disease-susceptible mice but not in the disease-resistant control mice in this study. These results show that CD1d deficiency impairs host resistance to a spirochete pathogen, and are the first example of a mutation that imparts Bb-resistant mice with the Ab and disease profile of a susceptible mouse strain.
UR - http://www.scopus.com/inward/record.url?scp=0034327173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034327173&partnerID=8YFLogxK
M3 - Article
C2 - 11046002
AN - SCOPUS:0034327173
VL - 165
SP - 4797
EP - 4801
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 9
ER -