Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion

Minelva R. Nanton, Sing Sing Way, Mark J. Shlomchik, Stephen J Mcsorley

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Typhoid fever and nontyphoidal bacteremia caused by Salmonella remain critical human health problems. B cells are required for protective immunity to Salmonella, but the mechanism of protection remains unclear. In this study, we immunized wild-type, B cell-deficient, Ab-deficient, and class-switched Ab-deficient mice with attenuated Salmonella and examined protection against secondary infection. As expected, wild-type mice were protected and B cell-deficient mice succumbed to secondary infection. Interestingly, mice with B cells but lacking secreted Ab or class-switched Ab had little deficiency in resistance to Salmonella infection. The susceptibility of B cell-deficient mice correlated with marked reductions in CD4 T cell IFN-γ production after secondary infection. Taken together, these data suggest that the primary role of B cells in acquired immunity to Salmonella is via the development of protective T cell immunity.

Original languageEnglish (US)
Pages (from-to)5503-5507
Number of pages5
JournalJournal of Immunology
Volume189
Issue number12
DOIs
StatePublished - Dec 15 2012

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Salmonella
Immunity
B-Lymphocytes
Antibodies
Coinfection
T-Lymphocytes
Salmonella Infections
Typhoid Fever
Adaptive Immunity
Bacteremia
Health

ASJC Scopus subject areas

  • Immunology

Cite this

Cutting edge : B cells are essential for protective immunity against Salmonella independent of antibody secretion. / Nanton, Minelva R.; Way, Sing Sing; Shlomchik, Mark J.; Mcsorley, Stephen J.

In: Journal of Immunology, Vol. 189, No. 12, 15.12.2012, p. 5503-5507.

Research output: Contribution to journalArticle

Nanton, Minelva R. ; Way, Sing Sing ; Shlomchik, Mark J. ; Mcsorley, Stephen J. / Cutting edge : B cells are essential for protective immunity against Salmonella independent of antibody secretion. In: Journal of Immunology. 2012 ; Vol. 189, No. 12. pp. 5503-5507.
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