TY - JOUR
T1 - Cutting edge
T2 - Antibody-dependent memory-like NK cells distinguished by FcRγ deficiency
AU - Zhang, Tianxiang
AU - Scott, Jeannine M.
AU - Hwang, Ilwoong
AU - Kim, Sung Jin
PY - 2013/2/15
Y1 - 2013/2/15
N2 - Because NK cells lack gene-recombination machinery and are thought to be relatively short-lived, it is unclear whether NK cells can mount long-term effective recall responses to reinfections by diverse pathogens. In this article, we report that FcRg-deficient NK cells, which we recently identified and termed g-NK cells, possess distinct memory features directed by FcR-mediated Abdependent target recognition. The presence of g-NK cells was associated with prior human CMV (HMCV) infection, yet g-NK cell responses were not restricted to HCMV-infected target cells. In the presence of virusspecific Abs, g-NK cells had greatly enhanced functional capabilities, superior to conventional NK cells, and were highly responsive to cells infected with either HCMV or HSV-1. Remarkably, the g -NK cell subset persisted long-term at nearly constant levels in healthy individuals. Therefore, FcRγ deficiency distinguishes an Ab-dependent memory-like NK cell subset with enhanced potential for broad antiviral responses.
AB - Because NK cells lack gene-recombination machinery and are thought to be relatively short-lived, it is unclear whether NK cells can mount long-term effective recall responses to reinfections by diverse pathogens. In this article, we report that FcRg-deficient NK cells, which we recently identified and termed g-NK cells, possess distinct memory features directed by FcR-mediated Abdependent target recognition. The presence of g-NK cells was associated with prior human CMV (HMCV) infection, yet g-NK cell responses were not restricted to HCMV-infected target cells. In the presence of virusspecific Abs, g-NK cells had greatly enhanced functional capabilities, superior to conventional NK cells, and were highly responsive to cells infected with either HCMV or HSV-1. Remarkably, the g -NK cell subset persisted long-term at nearly constant levels in healthy individuals. Therefore, FcRγ deficiency distinguishes an Ab-dependent memory-like NK cell subset with enhanced potential for broad antiviral responses.
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U2 - 10.4049/jimmunol.1203034
DO - 10.4049/jimmunol.1203034
M3 - Article
C2 - 23345329
AN - SCOPUS:84873565353
VL - 190
SP - 1402
EP - 1406
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 4
ER -