Cutaneous vascular malformation in a guinea pig (Cavia porcellus)

Anna Osofsky, Hilde E V De Cock, Lisa A Tell, Aimee J. Norris, Stephen D White

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A skin lesion classified as a vascular malformation is reported in a young-adult, female guinea pig. The physical examination revealed a 3 x 2-cm irregularly shaped violaceous plaque located on the left caudal flank. The surface of the plaque was ulcerated and bled intermittently, resulting in fatal blood loss. On histology the mass consisted of variably sized vascular spaces filled with red blood cells and variable amounts of extramedullary haematopoietic cells, lined by well-differentiated endothelial cells often surrounded by one layer of spindle-shaped cells. Based on immunohistochemistry, the spindle cell population was confirmed to be smooth muscle cells and no proliferation of endothelial cells was found with the Ki67 proliferation marker. Histological and immunohistochemical findings were consistent with a vascular malformation. Classification of vascular malformations and potential treatments are discussed. To the authors' knowledge, this is the first reported case of a cutaneous vascular lesion in a guinea pig.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalVeterinary Dermatology
Volume15
Issue number1
DOIs
StatePublished - Feb 2004

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Keywords

  • Arterial
  • Guinea pig
  • Skin
  • Vascular malformation

ASJC Scopus subject areas

  • veterinary(all)

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