Cutaneous histiocytic sarcoma with E-cadherin expression in a Pembroke Welsh Corgi dog

Ayano Hirako, Akihiko Sugiyama, Masashi Sakurai, Kiyokazu Ozaki, Hiroki Sakai, Takashi Takeuchi, Takehito Morita, Peter F Moore

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An 11-year-old male neutered Pembroke Welsh Corgi dog displayed a mass measuring 7.5 cm × 6.6 cm × 1.6 cm in the skin. Neoplastic tissue was nonencapsulated, and the neoplastic cells showed infiltrative growth into the surrounding tissue on microscopic examination. The neoplastic tissue was mainly located from the dermis to the subcutis. Epidermotropism of neoplastic cells was not observed. The tissue was composed of irregular, solid nests of round to polygonal cells. Nests were separated by fine fibrovascular stroma. Mitotic index was high (7.90 ± 0.38 per high power field) and extensive necrosis was observed in the neoplastic tissue. Vascular invasion was often observed in the neoplastic tissue. Neoplastic cells were positive for vimentin, HLA-DR antigen, Iba1, CD18, and E-cadherin, but cells did not express cytokeratin, S100, CD20, CD79α, CD3, MUM-1, lambda light chain, kappa light chain, lysozyme, CD204, or CD11d by immunohistochemistry. Electron microscopic analysis revealed dendrites on these cells. From the above-mentioned findings, the tumor was diagnosed as a cutaneous histiocytic sarcoma with E-cadherin expression. It is possible that neoplastic cells in the present case were derived from cutaneous Langerhans cell. To our knowledge, cutaneous histiocytic sarcoma with E-cadherin expression in domestic animals has not been previously diagnosed in domestic animals.

Original languageEnglish (US)
Pages (from-to)589-595
Number of pages7
JournalJournal of Veterinary Diagnostic Investigation
Volume27
Issue number5
DOIs
StatePublished - Sep 28 2015

Fingerprint

Histiocytic Sarcoma
cadherins
sarcoma
Cadherins
Dogs
Skin
dogs
domestic animals
Domestic Animals
nests
Langerhans cells
dermis
vimentin
dendrites
Light
cells
Mitotic Index
Langerhans Cells
lysozyme
blood vessels

Keywords

  • Dogs
  • E-cadherin
  • histiocytic sarcoma
  • skin

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)

Cite this

Cutaneous histiocytic sarcoma with E-cadherin expression in a Pembroke Welsh Corgi dog. / Hirako, Ayano; Sugiyama, Akihiko; Sakurai, Masashi; Ozaki, Kiyokazu; Sakai, Hiroki; Takeuchi, Takashi; Morita, Takehito; Moore, Peter F.

In: Journal of Veterinary Diagnostic Investigation, Vol. 27, No. 5, 28.09.2015, p. 589-595.

Research output: Contribution to journalArticle

Hirako, Ayano ; Sugiyama, Akihiko ; Sakurai, Masashi ; Ozaki, Kiyokazu ; Sakai, Hiroki ; Takeuchi, Takashi ; Morita, Takehito ; Moore, Peter F. / Cutaneous histiocytic sarcoma with E-cadherin expression in a Pembroke Welsh Corgi dog. In: Journal of Veterinary Diagnostic Investigation. 2015 ; Vol. 27, No. 5. pp. 589-595.
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