Abstract
Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. LP can involve the skin or mucous membranes including the oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. It has different variants based on the morphology of the lesions and the site of involvement. The literature suggests that certain presentations of the disease such as esophageal or ophthalmological involvement are underdiagnosed. The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. LP can significantly affect the quality of life of patients as well. Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP. LP is a T-cell mediated immunologic disease but the responsible antigen remains unidentified. In this paper, we review the history, epidemiology, and clinical subtypes of LP. We also review the histopathologic aspects of the disease, differential diagnoses, immunopathogenesis, and the clinical and genetic correlations.
| Original language | English (US) |
|---|---|
| Article number | 742826 |
| Journal | The Scientific World Journal |
| Volume | 2014 |
| DOIs | |
| State | Published - 2014 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Environmental Science(all)
- Medicine(all)
Cite this
Cutaneous and mucosal lichen planus : A comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. / Gorouhi, Farzam; Davari, Parastoo; Fazel, Nasim.
In: The Scientific World Journal, Vol. 2014, 742826, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cutaneous and mucosal lichen planus
T2 - A comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis
AU - Gorouhi, Farzam
AU - Davari, Parastoo
AU - Fazel, Nasim
PY - 2014
Y1 - 2014
N2 - Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. LP can involve the skin or mucous membranes including the oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. It has different variants based on the morphology of the lesions and the site of involvement. The literature suggests that certain presentations of the disease such as esophageal or ophthalmological involvement are underdiagnosed. The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. LP can significantly affect the quality of life of patients as well. Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP. LP is a T-cell mediated immunologic disease but the responsible antigen remains unidentified. In this paper, we review the history, epidemiology, and clinical subtypes of LP. We also review the histopathologic aspects of the disease, differential diagnoses, immunopathogenesis, and the clinical and genetic correlations.
AB - Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. LP can involve the skin or mucous membranes including the oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. It has different variants based on the morphology of the lesions and the site of involvement. The literature suggests that certain presentations of the disease such as esophageal or ophthalmological involvement are underdiagnosed. The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. LP can significantly affect the quality of life of patients as well. Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP. LP is a T-cell mediated immunologic disease but the responsible antigen remains unidentified. In this paper, we review the history, epidemiology, and clinical subtypes of LP. We also review the histopathologic aspects of the disease, differential diagnoses, immunopathogenesis, and the clinical and genetic correlations.
UR - http://www.scopus.com/inward/record.url?scp=84896898920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896898920&partnerID=8YFLogxK
U2 - 10.1155/2014/742826
DO - 10.1155/2014/742826
M3 - Article
C2 - 24672362
AN - SCOPUS:84896898920
VL - 2014
JO - The Scientific World Journal
JF - The Scientific World Journal
SN - 2356-6140
M1 - 742826
ER -